{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:21:21Z","timestamp":1789518081144,"version":"build-2803163510"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background: &lt;\/i&gt;Obstructive uropathy is argued to involve an ischemia-type tissue injury. Further, hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) constitutes a nuclear transcription factor normally upregulated under hypoxic conditions. We hypothesized that HIF-1\u03b1 is expressed in the hydronephrotic renal pelvis, as a result of tissue hypoxia. &lt;i&gt;Patients and Methods: &lt;\/i&gt;Renal pelvis tissue specimens were obtained from 2 patient groups. Group 1 (controls, n = 10) consisted of patients who underwent nephrectomy due to nonobstructive renal malignancy. Group 2 (n = 18) consisted of patients who underwent open procedures due to intractable hydronephrosis, not amenable to conservative measures. HIF-1\u03b1 detection was conducted via immunohistochemical techniques, while histological alterations in both groups were also recorded. &lt;i&gt;Results:&lt;\/i&gt; Smooth muscle hypertrophy and urothelial hyperplasia were major findings in group 2. HIF-1\u03b1-positive cells (fibroblasts and occasionally macrophages), mainly localized in the stroma, were also found to a greater extent in group 2 (p = 0.0066). &lt;i&gt;Conclusion:&lt;\/i&gt; We conclude that HIF-1\u03b1 is mainly expressed in stroma fibroblasts of the hydronephrotic renal pelvis, implying the presence of significant tissue hypoxia at the dilated upper urinary tract.<\/jats:p>","DOI":"10.1159\/000176023","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T16:06:40Z","timestamp":1232554000000},"page":"38-42","source":"Crossref","is-referenced-by-count":11,"title":["Hydronephrosis Promotes Expression of Hypoxia-Inducible Factor 1\u03b1"],"prefix":"10.1159","volume":"82","author":[{"given":"Konstantinos G.","family":"Stravodimos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Koritsiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas C.","family":"Lazaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Agrogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Koutalellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Constantinides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios","family":"Patsouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Kapetanakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Zervas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00775.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089%2F089277902753483727"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1089%2F089277902320913323"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000092792.97122.E0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00071.2006"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200102000-00087"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2965354-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1997.95"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00334.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000091783"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.22.15.5319-5336.2002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Femboj%2F17.22.6573"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.02236-05"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02893436"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6602245"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2962222-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089%2F089277901750426300"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/176023","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/176023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:21:54Z","timestamp":1745454114000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000176023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000176023","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}