{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:28:15Z","timestamp":1762100895882,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Objectives:<\/i> To investigate the alterations of urine transforming growth factor-\u03b21 (TGF-\u03b21) and basic fibroblast growth factor (bFGF) following bladder outlet obstruction (BOO) in rats and to determine their correlation with the impaired detrusor contractibility. <i>Methods:<\/i> Wistar rats were divided into control, 2-week BOO 6-week and BOO groups. Impaired detrusor contractibility was quantified by measuring detrusor contraction force (DCF) of detrusor strip stimulated by carbachol. The enzyme-linked immunosorbent assay method was used to determine the urine levels of the 2 factors. Correlation analysis was conducted between DCF and urine levels of the 2 factors to see if there was an association between them after BOO. <i>Results:<\/i> DCF was found to be significantly lower in the 6-week BOO group than in the 2-week BOO and control groups. There is no significant difference regarding urine TGF-\u03b21 between the 2-week BOO and control groups (p > 0.05). Urine TGF-\u03b21 level in the 6-week BOO group was significantly higher than in the 2-week BOO (p < 0.05) and control groups (p < 0.05). There existed a negative correlation between DCF and urine TGF-\u03b21 (p < 0.05). <i>Conclusions:<\/i> In an animal model, our results have suggested the potential role of urine TGF-\u03b21 as a noninvasive biomarker to predict detrusor contractibility after BOO.<\/jats:p>","DOI":"10.1159\/000176024","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T16:06:40Z","timestamp":1232554000000},"page":"43-47","source":"Crossref","is-referenced-by-count":13,"title":["Alterations of Urine TGF-\u03b21 and bFGF following Bladder Outlet Obstruction: A Predictor for Detrusor Contractibility?"],"prefix":"10.1159","volume":"82","author":[{"given":"Benkang","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Laudon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingxia","family":"Ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhishun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-4096.2003.05059.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1080%2F00365590310014751"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000102685.44036.b9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.annrmp.2006.02.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2005.06.124"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00191215"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1442-2042.2001.00356.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2800%2900591-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200102000-00033"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-199805000-00105"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2800%2900886-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00925673"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000079700"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2F1096-8628%2820000717%2993%3A2%3C132%3A%3AAID-AJMG10%3E3.0.CO%3B2-%23"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fnau.20121"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fnau.20109"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/176024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/176024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:21:55Z","timestamp":1745454115000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000176024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000176024","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2009]]}}}