{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:54:56Z","timestamp":1760982896253,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[1980,1,1]],"date-time":"1980-01-01T00:00:00Z","timestamp":315532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1980,1,1]],"date-time":"1980-01-01T00:00:00Z","timestamp":315532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[1980]]},"abstract":"<jats:p>Tyrosine and tryptophan have been assayed spectrofluorometrically in postmortem human brain areas of patients with Parkinson\u2019s disease treated orally with or without 3,4-dihydroxyphenylalanine (&lt;i&gt;L&lt;\/i&gt;-dopa) plus the peripherally acting decarboxylase inhibitor benserazide. Tyrosine as well as tryptophan decreased significantly after treatment with &lt;i&gt;L&lt;\/i&gt;-dopa, thus showing a competitive action of &lt;i&gt;L&lt;\/i&gt;-dopa to other aromatic amino acids on human brain uptake. It is suggested that some of the side effects of &lt;i&gt;L&lt;\/i&gt;-dopa treatment in Parkinson\u2019s disease are due to a disturbance in the brain and neural uptake of other, specially aromatic and branched-chain amino acids. An influence of &lt;i&gt;L&lt;\/i&gt;-dopa administration on protein synthesis also cannot be excluded.<\/jats:p>","DOI":"10.1159\/000176359","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T13:59:46Z","timestamp":1227103186000},"page":"417-423","source":"Crossref","is-referenced-by-count":15,"title":["&lt;i&gt;L&lt;\/i&gt;-Dopa Competes with Tyrosine and Tryptophan for Human Brain Uptake"],"prefix":"10.1159","volume":"24","author":[{"given":"P.","family":"Riederer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,18]]},"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/176359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/176359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:24:54Z","timestamp":1745454294000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000176359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000176359","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"type":"print","value":"0250-6807"},{"type":"electronic","value":"1421-9697"}],"subject":[],"published":{"date-parts":[[1980]]}}}