{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:44:33Z","timestamp":1778276673027,"version":"3.51.4"},"reference-count":44,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T00:00:00Z","timestamp":1227225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T00:00:00Z","timestamp":1227225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Recent studies suggest that expression of the transforming growth factor-\u03b2 (TGF-\u03b2)-inducible gene-h3 (\u03b2ig-h3) and its anti-lysosomal activity may be responsible for the development of albuminuria and cardiovascular disease associated with hypertension. &lt;i&gt;Methods:&lt;\/i&gt; We evaluated the proposed linkage using the spontaneously hypertensive rat (SHR) and Wistar-Kyoto rat models. The kidney and left ventricular weight\/body weight ratios were measured and cardiac collagen deposition was analyzed by Masson\u2019s trichrome stain. Renal and cardiac TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt; and \u03b2ig-h3 expression were determined by real-time reverse transcription-polymerase chain reaction, and renal and cardiac cathepsin B and L activities were measured as an indicator of lysosomal proteolytic activity. &lt;i&gt;Results:&lt;\/i&gt; SHR exhibited increased levels of intact urinary albumin without significant change in total albumin (intact plus albumin-derived material) excretion. This was accompanied by renal hypertrophy, increased renal \u03b2ig-h3 expression, and reduced renal cathepsin B and L activities. At the same time, increased cardiac TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt; and \u03b2ig-h3 expression and reduced cardiac cathepsin B activity was identified in SHR in addition to cardiac hypertrophy and increased collagen deposition. All these changes could be ameliorated with ramipril treatment. &lt;i&gt;Conclusions:&lt;\/i&gt; These findings implicate for the first time \u03b2ig-h3 expression and lysosomal activity as a key factor in the induction of albuminuria and cardiovascular disease associated with hypertension.<\/jats:p>","DOI":"10.1159\/000176535","type":"journal-article","created":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T12:02:29Z","timestamp":1227268949000},"page":"454-464","source":"Crossref","is-referenced-by-count":9,"title":["Hypertension-Mediated Albuminuria Is Associated with Reduced Lysosomal Activity in the Kidney and the Heart"],"prefix":"10.1159","volume":"29","author":[{"given":"Lucinda M.","family":"Hilliard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leileata M.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne 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