{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:07:10Z","timestamp":1765825630214,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; It is currently unknown whether a newly developed endoscopic ultrasound (EUS) program can produce results similar to those of experienced EUS centers. We therefore prospectively evaluated the diagnostic accuracy and major complications of EUS-guided fine needle aspiration (EUS-FNA) in a newly developed EUS program. &lt;i&gt;Methods:&lt;\/i&gt; All procedures were performed by a single endosonographer in the presence of a cytopathologist. Reference standard for classification of final disease included: surgical resection, death from disease progression and repeat radiologic and\/or clinical follow-up. Major complications were defined as oversedation, and those that resulted in a physician or emergency department visits, hospitalization, or death. &lt;i&gt;Results:&lt;\/i&gt; 540 patients (median age 63 years, 77% white) underwent EUS-FNAs of 656 lesions: lymph nodes (LNs, n = 248), solid pancreatic masses (SPMs, n = 229), cystic pancreatic masses (CPM, n = 57), mural lesions (n = 41), bile duct\/gallbladder (n = 28), liver (n = 17), mediastinum\/lung (n = 17), adrenal (n = 15), spleen (n = 3) and kidney (n = 1). SPMs and bile duct\/gallbladder lesions were more likely to have suspicious\/atypical cytology when compared to other lesions (8.7 vs. 4.6%; p = 0.04) and required more passes to achieve a tissue diagnosis (p &lt; 0.001). The overall sensitivity, specificity, PPV, NPV and accuracy of EUS-FNA was 91.7, 97.1, 98.1, 87.7 and 93.8%, respectively. Six patients (1.1%) (95% CI 0.4\u20132.4) experienced a major complication. One patient died shortly after the procedure due to preexisting pulmonary embolus (0.18%). &lt;i&gt;Conclusion:&lt;\/i&gt; EUS-FNA is highly accurate and safe in sampling a variety of peri-intestinal organs and lymph nodes. With adequate third-tier training, a newly developed program can produce results similar to those from expert EUS centers.<\/jats:p>","DOI":"10.1159\/000177022","type":"journal-article","created":{"date-parts":[[2009,1,31]],"date-time":"2009-01-31T17:11:36Z","timestamp":1233421896000},"page":"356-363","source":"Crossref","is-referenced-by-count":46,"title":["Prospective Assessment of Diagnostic Utility and Complications of Endoscopic Ultrasound-Guided Fine Needle Aspiration"],"prefix":"10.1159","volume":"26","author":[{"given":"Mohamad A.","family":"Eloubeidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashutosh","family":"Tamhane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2892%2970385-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.athoracsur.2004.06.089"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2897%2970164-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.44.5.720"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2004.04064.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.10714"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1309%2FMFRF-J0XY-JLN8-NVDP"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fge.1999.v50.97111"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.07020.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1542-3565%2804%2900005-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fadpa.2002.35741"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2802%2970361-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2802%2970362-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3ADDAS.0000007866.89357.dd"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2003.07472.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2006.00852.x"}],"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/177022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/177022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:31:56Z","timestamp":1745454716000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000177022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000177022","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"type":"print","value":"0257-2753"},{"type":"electronic","value":"1421-9875"}],"subject":[],"published":{"date-parts":[[2008]]}}}