{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:57:41Z","timestamp":1770433061252,"version":"3.49.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,11,27]],"date-time":"2008-11-27T00:00:00Z","timestamp":1227744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,11,27]],"date-time":"2008-11-27T00:00:00Z","timestamp":1227744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; We examined the risk of narcolepsy associated with active and passive smoking among genetically susceptible individuals. &lt;i&gt;Methods:&lt;\/i&gt; We conducted a popula- tion-based case-control study in King County, Wash., USA. Between 2001 and 2005, we enrolled 67 cases through physicians and public outreach, and 95 controls through random-digit dialing. Subjects were aged between 18 and 50 years and positive for HLA DQB1*0602. All subjects were administered in-person interviews about their history of active and passive smoking. &lt;i&gt;Results:&lt;\/i&gt; We observed an increased risk of narcolepsy associated with having lived with two or more household smokers (odds ratio, OR = 5.1; 95% confidence interval, CI: 1.6, 12.1); with a grandparent or a sibling who smoked (OR = 3.0; 95% CI: 1.1, 8.3); with a non-family household member who smoked (OR = 3.7; 95% CI: 1.6, 8.6); and with an unrelated smoker for 1\u20132 years (OR = 3.1; 95% CI: 1.0, 9.0). The risk of narcolepsy was not associated with exposure to smoke at work or with active smoking before age 21 or before age of narcolepsy onset. &lt;i&gt;Conclusion:&lt;\/i&gt; Passive smoking may be a risk factor for narcolepsy in subjects with HLA DQB1*0602. Future studies could help clarify whether passive smoking is an important etiologic component of narcolepsy among genetically susceptible individuals.<\/jats:p>","DOI":"10.1159\/000177037","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T14:18:13Z","timestamp":1227968293000},"page":"114-121","source":"Crossref","is-referenced-by-count":23,"title":["Active and Passive Smoking and Risk of Narcolepsy in People with HLA DQB1*0602: A Population-Based Case-Control Study"],"prefix":"10.1159","volume":"32","author":[{"given":"Thanh G.N.","family":"Ton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.T.","family":"Longstreth, Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Koepsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-4328%2800%2900206-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10277"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biopha.2003.12.004"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000082998"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm198"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960237-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.genom.4.070802.110432"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0258%2819990330%2918%3A6%3C681%3A%3AAID-SIM71%3E3.0.CO%3B2-R"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Faje%2Fkwm050"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00001648-200211000-00026"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-4356%2894%2990101-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109%2F02813439508996775"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-1886"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00019052-200306000-00017"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2007.03.028"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.11.044"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/177037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/177037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:32:02Z","timestamp":1745454722000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000177037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,27]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000177037","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,27]]}}}