{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:13:12Z","timestamp":1777770792667,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>To determine the electrophysiological effects of propofol and to explain the potential mechanism(s) whereby it causes bradyarrhythmias, 10 closed-chest pigs weighing 20-25 kg were studied. Each animal was premedicated by intramuscular administration of ketamine hydrochloride, intubated, and mechanically ventilated. Femoral arterial and venous catheters were placed, and a comprehensive electrophysiologic evaluation was performed at baseline and after two doses (1 mg\/kg i.v. bolus and 0.1 mg\/kg\/min infusion and an extra 1-mg\/kg i.v. bolus and 0.2 mg\/kg\/min infusion) of propofol. The electrophysiological effects obtained on low- and high-dose propofol were compared to baseline values. Propofol caused a dose-related decrease in sinus cycle length (baseline 565 \u00b1 36 ms, low-dose propofol 541 \u00b1 28, high-dose propofol 527 \u00b1 26 ms; p &lt; 0.05), a prolongation of the corrected sinus node recovery time (baseline 119 \u00b1 35 ms, low-dose propofol 126 \u00b1 32, high-dose propofol 130 \u00b1 30 ms; p &lt; 0.01), and an increase in the His-ventricular interval (baseline 33 \u00b1 4 ms, low-dose propofol 36 \u00b1 4, high-dose propofol 40 \u00b1 3 ms; p &lt; 0.005). All other electrophysiological parameters remained unchanged, and there were no cases of spontaneous atrioventricular block or sinus pauses. We conclude that propofol causes dose-related depression of sinus node and His-Purkinje system functions, but has no effect on the atrioventricular node function and on the conduction properties of atrial and ventricular tissues in normal pig hearts.<\/jats:p>","DOI":"10.1159\/000177113","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T08:59:46Z","timestamp":1227085186000},"page":"319-324","source":"Crossref","is-referenced-by-count":40,"title":["Electrophysiological Effects of Propofol on the Normal Cardiac Conduction System"],"prefix":"10.1159","author":[{"given":"Luis A.","family":"Pires","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoei K.","family":"Stephen Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B.","family":"Wagshal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama S.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,19]]},"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000177113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:40:18Z","timestamp":1777480818000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000177113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000177113","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,19]]}}}