{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T01:14:27Z","timestamp":1777770867905,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T00:00:00Z","timestamp":1227052800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"abstract":"<jats:p>This study investigated the effects of chronic \u03b2-blockade on the pathophysiology of heart failure following induction of aortic regurgitation (AR). Nine rabbits with AR were administered propranolol continuously for 7 days (AR+P), 8 rabbits with AR received vehicle for the same period (AR+C), and 7 rabbits underwent sham operation. Cardiac output was lower and the left-ventricular end-diastolic pressure was higher in AR+C than in sham-operated rabbits, but there was no difference in the right-ventricular end-diastolic pressure between the two groups. Down-regulation of \u03b2-adrenoceptors was observed in the left ventricle, but not in the right ventricle. All of these variables were reversed in AR+P. In left-ventricular failure produced by AR, (1) the augmentation of adrenergic drive occurred selectively in the left ventricle, and (2) propranolol blunted adrenergic drive and played a protective role against myocardial damage.<\/jats:p>","DOI":"10.1159\/000177371","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T08:59:46Z","timestamp":1227085186000},"page":"418-424","source":"Crossref","is-referenced-by-count":7,"title":["Beta-Blockade Prevents Ventricular Failure following Aortic Regurgitation in Rabbits"],"prefix":"10.1159","author":[{"given":"Masahiro","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Wainai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Nagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunnosuke","family":"Hand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,19]]},"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000177371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:41:33Z","timestamp":1777480893000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000177371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000177371","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,19]]}}}