{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:27:40Z","timestamp":1792168060021,"version":"4.4.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Peripheral precocious puberty (PPP) results from sex steroid exposure by a process other than activation of the hypothalamic-pituitary-gonadal axis. It is much less common than central precocious puberty and may be congenital or acquired. Causes of PPP range from well-characterized genetic mutations to those conditions without a known etiology (idiopathic). Medical evaluation and treatment of affected children is guided by the presenting features and ultimate diagnosis. &lt;i&gt;Conclusions:&lt;\/i&gt; Carefully executed and collaborative multicenter investigations are essential to expand our knowledge of the underlying pathophysiology, optimal therapy and ultimate outcomes in children with PPP.<\/jats:p>","DOI":"10.1159\/000178041","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T08:53:22Z","timestamp":1232441602000},"page":"64-67","source":"Crossref","is-referenced-by-count":22,"title":["Peripheral Precocious Puberty: Causes and Current Management"],"prefix":"10.1159","volume":"71","author":[{"given":"Erica A.","family":"Eugster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.20233"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-002-0727-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.21074"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3ANEON.0000013499.74404.81"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.114.1.282"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177%2F000992289803701204"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa064725"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-1227"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.12.046"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpedsurg.2007.04.021"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-2350"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-2090"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2803%2900128-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.1.175"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2006.04.027"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:56:05Z","timestamp":1745452565000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000178041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":15,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000178041","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}