{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:08:20Z","timestamp":1791101300464,"version":"4.1.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>The anti-angiogenic factors soluble fms-like tyrosine kinase (sFlt)-1 and soluble endoglin (sEng) have been shown to be of importance in angiogenesis by sequestering and inhibiting vascular endothelial growth factor, placenta-like growth factor and transforming growth factor-\u03b2&lt;sub&gt;1&lt;\/sub&gt; signaling. Given the potential role of angiogenesis in the pathophysiology of sickle cell disease (SCD)-related complications, serum levels of sFlt-1 and sEng were determined in SCD patients and controls. Both sFlt-1 (p = 0.002) and sEng (p = 0.004) were elevated in patients during clinically asymptomatic SCD with no further increment during painful crisis. These data suggest that sFlt-1 and sEng may be important in the regulation of angiogenesis in SCD.<\/jats:p>","DOI":"10.1159\/000178143","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T14:20:02Z","timestamp":1227968402000},"page":"130-133","source":"Crossref","is-referenced-by-count":15,"title":["Increased Serum Levels of Anti-Angiogenic Factors Soluble fms-Like Tyrosine Kinase and Soluble Endoglin in Sickle Cell Disease"],"prefix":"10.1159","volume":"120","author":[{"given":"P.P.","family":"Landburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Elsenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.B.","family":"Schnog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Duits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2917192-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm0603-653"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2006.06103.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa055352"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-02-074849"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2006.06074.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1533"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2004.05295.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra0706596"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2002-11-3422"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1429"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00062752-200303000-00001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M104536200"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M207160200"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8652%28199805%2958%3A1%3C61%3A%3AAID-AJH11%3E3.0.CO%3B2-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3324%2Fhaematol.12152"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136%2Fbjo.2004.058164"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:57:04Z","timestamp":1745452624000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000178143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000178143","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}