{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:50:24Z","timestamp":1745470224989,"version":"3.40.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[1971,1,1]],"date-time":"1971-01-01T00:00:00Z","timestamp":31536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1971,1,1]],"date-time":"1971-01-01T00:00:00Z","timestamp":31536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[1971]]},"abstract":"<jats:p>The fortuitous results of experiments showing a higher incidence of tumors after the administration of &lt;sup&gt;125&lt;\/sup&gt;I than after &lt;sup&gt;131&lt;\/sup&gt;I, raised the question of the relative biological effectiveness of &lt;sup&gt;125&lt;\/sup&gt;I. A reevaluation of the microdosimetry of &lt;sup&gt;125&lt;\/sup&gt;I in the thyroid follicle revealed that due to the low energy electrons\u2013especially the Auger electrons\u2013the radiation dose delivered to the cell colloid interface is ca. 4 or more times greater than that from an equivalent amount of &lt;sup&gt;131&lt;\/sup&gt;I. At the same time, the nucleus dose of the cell is reduced by up to 80% as compared to that of &lt;sup&gt;131&lt;\/sup&gt;1. &lt;sup&gt;125&lt;\/sup&gt;I was therefore suggested as a suitable substitute for the treatment of thyrotoxicosis. On the basis of the radiation dose delivered to the nucleus, a dose of 40 mCi on the average was proposed. On the other hand, basing the dose on the radiation delivered to the colloid-cell boundary, which is probably the site of the sensitive hormonogenic mechanism, much smaller amounts, in the range of 2\u20133.5 mCi &lt;sup&gt;125&lt;\/sup&gt;I were administered. The results obtained in this series of 35 patients, with a follow-up of up to a year have so far partially justified this approach. A 20% failure was noted which suggests the use of carefully adjusted higher doses, most probably in the range of 4\u20136 mCi.<\/jats:p>","DOI":"10.1159\/000178228","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T08:37:55Z","timestamp":1227515875000},"page":"115-128","source":"Crossref","is-referenced-by-count":1,"title":["The Problem of Iodine-125 for Treatment of Thyrotoxicosis"],"prefix":"10.1159","volume":"2","author":[{"given":"Z.","family":"Lewitus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rechnic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Laor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ben-Porath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Feige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,21]]},"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:57:50Z","timestamp":1745452670000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000178228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000178228","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[1971]]}}}