{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:49:04Z","timestamp":1783648144319,"version":"3.55.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> Sexual dysfunction is a poorly studied aspect of quality of life in patients with midgut carcinoid tumours. We investigated whether carcinoid patients experience sexual problems.<i> Methods:<\/i> Patients with metastatic midgut carcinoid tumours filled in a validated questionnaire for sexual dysfunction. The prevalence of dysfunction on the subscales arousal, erection, lubrication, orgasm and dyspareunia was compared to a Dutch reference population. Plasma concentration of gonadal hormones, tryptophan and urinary 5-hydroxyindolacetic acid concentrations were measured. <i>Results:<\/i> 43 patients were studied, 27 men and 16 women. Sexual dysfunction was present in 29.6% of men and 6.3% of women. The prevalence of sexual dysfunction on the different subscales did not differ from the reference population. Patients with a sexual dysfunction had, compared to those without a sexual dysfunction, a longer duration of disease, 95.3 months (range 5.4\u2013314.5) versus 18.6 months (range 0.6\u2013167.9) (p = 0.024), lower plasma tryptophan concentration (\u00b1SD) of 31.5 \u00b1 16.1 and 48.9 \u00b1 14.5 \u03bcmol\/l (p = 0.031), and more often used interferon-\u03b1, 50% of patients versus 10.5% of patients (p = 0.044). <i>Conclusion:<\/i> Patients with metastatic midgut carcinoid tumours do not experience sexual problems more often than a reference population. Male patients with sexual dysfunction are characterised by more long-standing disease and lower tryptophan concentration.<\/jats:p>","DOI":"10.1159\/000178754","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T16:15:27Z","timestamp":1227716127000},"page":"231-236","source":"Crossref","is-referenced-by-count":18,"title":["Sexual Function in Patients with Metastatic Midgut Carcinoid Tumours"],"prefix":"10.1159","volume":"89","author":[{"given":"Anouk N.A.","family":"van der Horst-Schrivers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"van Ieperen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.N. Machteld","family":"Wymenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Marike","family":"Boezen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willibrord C.M.","family":"Weijmar-Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido P.","family":"Kema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim G.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter W.","family":"de Herder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pax H.B.","family":"Willemse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thera P.","family":"Links","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth G.E.","family":"de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820010815%2992%3A4%2B%3C1008%3A%3AAID-CNCR1413%3E3.0.CO%3B2-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186%2F1477-7525-5-18"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080%2F02841860152703445"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00000441-197410000-00002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.physbeh.2004.08.018"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F01.psy.0000126204.97565.91"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960197-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pharmthera.2005.12.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F85.5.365"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1373%2Fclinchem.2005.050062"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-4347%2800%2983867-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0009-8981%2875%2990009-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2800%2901091-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa067423"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.1.06007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22339"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.2.589"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-1245"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:02:51Z","timestamp":1745452971000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000178754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000178754","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}