{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:06Z","timestamp":1790695446171,"version":"4.1.0"},"reference-count":31,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Currently, autografts are the best treatment to any substantial cutaneous injury, and their success is well known as a burn therapy. However, autografts have been less successful in the treatment of chronic ulcers, and are usually a last-resort therapy because of infection at the injured site, high surgical expense, additional morbidity and engraftment failure. In addition, patients with burns covering more than 50% of their skin have limited donor sites for autograft harvest. Therefore, there is a great need for a cost-effective, user-friendly, tissue-engineered construct (TEC) that can provide successful treatments to both acute and chronic wounds in a wider repertoire of patients, including diabetics and the elderly. One approach to the challenge is to create a substitute for skin in vitro that can integrate into the engraftment site in vivo. An alternative is to engineer a biocompatible, resorbable matrix that can recruit the proper, native tissue cells to the injured site and induce them to heal the wound without scarring. This chapter reviews the 3 essential components of cutaneous wound healing, that is, cells, extracellular matrix molecules and bioactive molecules, that must be considered for designing TECs to potentially enhance the healing process. In nature, a \u2018dynamic reciprocity\u2019 exists amongst cells and extracellular matrix that is mediated by bioactive molecules at the site of injury. Thus, it is important to examine the interplay of all 3 components when engineering a TEC. This chapter also includes examples of commercially available products to highlight how researchers have already begun to find success in tissue engineering.<\/jats:p>","DOI":"10.1159\/000178867","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T13:47:13Z","timestamp":1233755233000},"page":"83-93","source":"Crossref","is-referenced-by-count":69,"title":["Tissue Engineering for Cutaneous Wounds: Selecting the Proper Time and Space for Growth Factors, Cells and the Extracellular Matrix"],"prefix":"10.1159","volume":"22","author":[{"given":"L.","family":"Macri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.F.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,2,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jid.5700715"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.burns.2007.03.020"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.cellbio.22.010305.104315"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semcancer.2005.05.001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fbies.950170206"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12500075"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.297.9.938"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.burns.2005.08.009"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clindermatol.2004.07.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1069210"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089%2Ften.1998.4.403"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053%2Fjoca.2001.0482"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.282.5391.1145"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2007.11.019"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1259%2Fbjr%2F25927054"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fnmat1249"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1089%2Ften.2006.12.3307"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1684"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.addr.2007.08.012"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.addr.2007.08.015"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.addr.2007.08.007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2006.06.044"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrm2125"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.addr.2007.08.014"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1092053"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biomaterials.2006.09.038"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038%2Fjid.2008.75"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M300171200"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2802%2903439-7"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1242%2Fjcs.00503"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0506004103"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/178867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:04:02Z","timestamp":1745453042000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000178867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000178867","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}