{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:35:45Z","timestamp":1790886945012,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pancreatology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1159\/000178884","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T10:27:44Z","timestamp":1229077664000},"page":"136-144","source":"Crossref","is-referenced-by-count":76,"title":["ATP-Binding Cassette C Transporters in Human Pancreatic Carcinoma Cell Lines"],"prefix":"10.1016","volume":"9","author":[{"given":"Wolfgang","family":"Hagmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Jesnowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Faissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Matthias","family":"L\u00f6hr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1159\/000178884_bib1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","article-title":"Cancer statistics, 2006","volume":"56","author":"Jemal","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"10.1159\/000178884_bib2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1586\/14737140.7.4.533","article-title":"Medical treatment of pancreatic cancer","volume":"7","author":"L\u00f6hr","year":"2007","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1159\/000178884_bib3","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ncpgasthep0469","article-title":"Is it possible to survive pancreatic cancer?","volume":"3","author":"L\u00f6hr","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1159\/000178884_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1200\/JCO.1988.6.3.469","article-title":"A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma","volume":"6","author":"Erlichman","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1159\/000178884_bib5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1200\/JCO.1989.7.4.425","article-title":"A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a mid-Atlantic oncology program study","volume":"7","author":"Lokich","year":"1989","journal-title":"J Clin Oncol"},{"key":"10.1159\/000178884_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1182\/blood.V81.1.151.151","article-title":"Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line","volume":"81","author":"Miyashita","year":"1993","journal-title":"Blood"},{"key":"10.1159\/000178884_bib7","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1182\/blood.V80.4.879.879","article-title":"Bcl-2 initiates a new category of oncogenes: regulators of cell death","volume":"80","author":"Korsmeyer","year":"1992","journal-title":"Blood"},{"key":"10.1159\/000178884_bib8","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/jnci\/92.16.1295","article-title":"A family of drug transporters: the multidrug resistance-associated proteins","volume":"92","author":"Borst","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1159\/000178884_bib9","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1038\/sj.onc.1206953","article-title":"The MRP family of drug efflux pumps","volume":"22","author":"Kruh","year":"2003","journal-title":"Oncogene"},{"key":"10.1159\/000178884_bib10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00424-006-0054-9","article-title":"Multidrug resistance-associated proteins 3, 4, and 5","volume":"453","author":"Borst","year":"2007","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1159\/000178884_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0005-2736(99)00169-8","article-title":"Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance","volume":"1461","author":"K\u00f6nig","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1159\/000178884_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrd1984","article-title":"Targeting multi-drug resistance in cancer","volume":"5","author":"Szakacs","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1159\/000178884_bib13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0026-895X(24)23190-4","article-title":"Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells","volume":"55","author":"Cui","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1159\/000178884_bib14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.taap.2004.10.012","article-title":"Multidrug resistance proteins: role of p-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense","volume":"204","author":"Leslie","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1159\/000178884_bib15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1349-7006.1996.tb00271.x","article-title":"Immunohistochemical localization of p-glycoprotein and expression of the multidrug resistance-1 gene in human pancreatic cancer: relevance to indicator of better prognosis","volume":"87","author":"Suwa","year":"1996","journal-title":"Jpn J Cancer Res"},{"key":"10.1159\/000178884_bib16","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00006676-200010000-00004","article-title":"Expression of the multidrug-resistance 1 (MDR1) gene and prognosis in human pancreatic cancer","volume":"21","author":"Lu","year":"2000","journal-title":"Pancreas"},{"key":"10.1159\/000178884_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-5793(98)00899-0","article-title":"cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)","volume":"433","author":"Kiuchi","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1159\/000178884_bib18","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1002\/hep.510290404","article-title":"Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane","volume":"29","author":"K\u00f6nig","year":"1999","journal-title":"Hepatology"},{"key":"10.1159\/000178884_bib19","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1073\/pnas.96.12.6914","article-title":"MRP3, an organic anion transporter able to transport anti-cancer drugs","volume":"96","author":"Kool","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1159\/000178884_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/labinvest.3780411","article-title":"Tissue distribution and induction of human multi-drug resistant protein 3","volume":"82","author":"Scheffer","year":"2002","journal-title":"Lab Invest"},{"key":"10.1159\/000178884_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00006676-200401000-00007","article-title":"Expression of multi-drug resistance proteins in rat and human chronic pancreatitis","volume":"28","author":"Schaarschmidt","year":"2004","journal-title":"Pancreas"},{"key":"10.1159\/000178884_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-2559.2002.01403.x","article-title":"Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays","volume":"41","author":"Sandusky","year":"2002","journal-title":"Histopathology"},{"key":"10.1159\/000178884_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ijc.20831","article-title":"Expression and localization of human multi-drug resistance protein (ABCC) family members in pancreatic carcinoma","volume":"115","author":"K\u00f6nig","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1159\/000178884_bib24","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1124\/dmd.105.007542","article-title":"Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats","volume":"34","author":"Slitt","year":"2006","journal-title":"Drug Metab Dispos"},{"key":"10.1159\/000178884_bib25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.1999.tb09509.x","article-title":"Immortalized pancreatic duct cells in vitro and in vivo","volume":"880","author":"Jesnowski","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1159\/000178884_bib26","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00428-003-0784-4","article-title":"A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform","volume":"442","author":"Sipos","year":"2003","journal-title":"Virchows Arch"},{"key":"10.1159\/000178884_bib27","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s004280100474","article-title":"Genetic profile of 22 pancreatic carcinoma cell lines: analysis of k-ras, p53, p16 and dpc4\/smad4","volume":"439","author":"Moore","year":"2001","journal-title":"Virchows Arch"},{"key":"10.1159\/000178884_bib28","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/labinvest.3700329","article-title":"Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and n-acetylcysteine","volume":"85","author":"Jesnowski","year":"2005","journal-title":"Lab Invest"},{"key":"10.1159\/000178884_bib29","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1172\/JCI118214","article-title":"Absence of the mdr1a p-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A","volume":"96","author":"Schinkel","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1159\/000178884_bib30","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1021\/bi027347u","article-title":"Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and trans-activating effects of the cyclopentenone prostaglandin, 15-deoxy-delta(12,14)prosta-glandin J2 in MCF7 breast cancer cells","volume":"42","author":"Paumi","year":"2003","journal-title":"Biochemistry"},{"key":"10.1159\/000178884_bib31","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.neuroscience.2005.10.025","article-title":"Human multidrug resistance protein 8 (MRP8\/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system","volume":"137","author":"Bortfeld","year":"2006","journal-title":"Neuroscience"},{"key":"10.1159\/000178884_bib32","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/jhep.2003.50331","article-title":"Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane","volume":"38","author":"Rius","year":"2003","journal-title":"Hepatology"},{"key":"10.1159\/000178884_bib33","doi-asserted-by":"crossref","first-page":"30069","DOI":"10.1074\/jbc.M005463200","article-title":"The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides","volume":"275","author":"Jedlitschky","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1159\/000178884_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1159\/000178884_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1432-1327.1999.00735.x","article-title":"Purification of the human apical conjugate export pump MRP2: reconstitution and functional characterization as substrate-stimulated ATPase","volume":"265","author":"Hagmann","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1159\/000178884_bib36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2133\/dmpk.20.452","article-title":"Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies","volume":"20","author":"Nishimura","year":"2005","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1159\/000178884_bib37","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1159\/000065091","article-title":"Ribosomal highly basic 23-kDa protein as a reliable standard for gene expression analysis","volume":"2","author":"Jesnowski","year":"2002","journal-title":"Pancreatology"},{"key":"10.1159\/000178884_bib38","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0002-9440(10)65211-X","article-title":"Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis","volume":"155","author":"Haber","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1159\/000178884_bib39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1067\/msy.2002.119192","article-title":"Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas","volume":"131","author":"Yen","year":"2002","journal-title":"Surgery"},{"key":"10.1159\/000178884_bib40","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1242\/jcs.03347","article-title":"Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay","volume":"120","author":"Schneiderhan","year":"2007","journal-title":"J Cell Sci"},{"key":"10.1159\/000178884_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tips.2005.11.007","article-title":"The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins","volume":"27","author":"van Herwaarden","year":"2006","journal-title":"Trends Pharmacol Sci"},{"issue":"part 1","key":"10.1159\/000178884_bib42","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1042\/bj3270305","article-title":"ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2","volume":"327","author":"Jedlitschky","year":"1997","journal-title":"Biochem J"},{"key":"10.1159\/000178884_bib43","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0167-4781(01)00270-6","article-title":"Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene","volume":"1520","author":"Bailey-Dell","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1159\/000178884_bib44","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1515\/BC.2002.107","article-title":"Reconstitution of transport-active multi-drug resistance protein 2 (MRP2: ABCC2) in proteoliposomes","volume":"383","author":"Hagmann","year":"2002","journal-title":"Biol Chem"},{"key":"10.1159\/000178884_bib45","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1158\/1535-7163.MCT-04-0291","article-title":"The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites","volume":"4","author":"Pratt","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1159\/000178884_bib46","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1158\/1535-7163.MCT-06-0529","article-title":"MRP8\/ ABCC11 directly confers resistance to 5-fluorouracil","volume":"6","author":"Oguri","year":"2007","journal-title":"Mol Cancer Ther"},{"key":"10.1159\/000178884_bib47","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00428-004-1053-x","article-title":"A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile","volume":"445","author":"Monti","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1159\/000178884_bib48","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000065068","article-title":"Acquired resistance of pancreatic cancer cells towards 5-fluorouracil and gemcitabine is associated with altered expression of apoptosis-regulating genes","volume":"62","author":"Shi","year":"2002","journal-title":"Oncology"},{"key":"10.1159\/000178884_bib49","first-page":"1798","article-title":"Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels","volume":"7","author":"Young","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1159\/000178884_bib50","doi-asserted-by":"crossref","first-page":"G640","DOI":"10.1152\/ajpgi.00354.2005","article-title":"Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione","volume":"290","author":"Rius","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1159\/000178884_bib51","doi-asserted-by":"crossref","first-page":"29509","DOI":"10.1074\/jbc.M304059200","article-title":"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2\u2032,3\u2032-dideoxycytidine and 9\u2032-(2\u2032-phosphonylmeth-oxyethyl)adenine","volume":"278","author":"Guo","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1159\/000178884_bib52","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1158\/1535-7163.MCT-06-0419","article-title":"Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells","volume":"5","author":"Lee","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1159\/000178884_bib53","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00280-006-0384-5","article-title":"Mechanisms of acquired chemo-resistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks","volume":"59","author":"Wang","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1159\/000178884_bib54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1349-7006.2007.00424.x","article-title":"Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs","volume":"98","author":"Ooyama","year":"2007","journal-title":"Cancer Sci"},{"key":"10.1159\/000178884_bib55","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1245\/s10434-007-9583-5","article-title":"Development and characterization of gemcitabine-resistant pancreatic tumor cells","volume":"14","author":"Shah","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1159\/000178884_bib56","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1038\/sj.onc.1206390","article-title":"Role of NF-kB and Akt\/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death","volume":"22","author":"Arlt","year":"2003","journal-title":"Oncogene"},{"key":"10.1159\/000178884_bib57","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.onc.1205117","article-title":"Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kB signaling","volume":"21","author":"Kuo","year":"2002","journal-title":"Oncogene"},{"key":"10.1159\/000178884_bib58","doi-asserted-by":"crossref","first-page":"5674","DOI":"10.1038\/sj.onc.1210356","article-title":"Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport","volume":"26","author":"Sims-Mourtada","year":"2007","journal-title":"Oncogene"}],"container-title":["Pancreatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390309800793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1424390309800793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T23:53:44Z","timestamp":1738799624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1424390309800793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":58,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S1424390309800793"],"URL":"https:\/\/doi.org\/10.1159\/000178884","relation":{},"ISSN":["1424-3903"],"issn-type":[{"value":"1424-3903","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}