{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:02:46Z","timestamp":1777910566410,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>Les auteurs rapportent 27 observations anatomo-cliniques, chez I\u2019enfant, de \u00absyndrome h\u00e9molytique et ur\u00e9mique\u00bb caract\u00e9ris\u00e9 par la survenue simultan\u00e9e d\u2019une an\u00e9mie h\u00e9molytique, d\u2019une atteinte r\u00e9nale, d\u2019une thrombop\u00e9nie et de troubles neurologiques qui sont plus inconstants. L\u2019atteinte r\u00e9nale se manifeste soit par une anurie, soit par une n\u00e9phropathie de type particulier: ur\u00e9mie tr\u00e8s \u00e9lev\u00e9e, h\u00e9maturie constante, prot\u00e9inurie abondante s\u2019accompagnant souvent d\u2019une hypoprotid\u00e9mie et parfois d\u2019un syndrome n\u00e9phrotique complet, perte r\u00e9nale d\u2019eau et d\u2019electrolytes, de sodium et de potassium, hypertension art\u00e9rielle pr\u00e9coce ou retard\u00e9e. Les convulsions inaugurales sont fr\u00e9quentes Certains cas sont compl\u00e8tement curables, surtout chez le nourrisson, mais des rechutes ult\u00e9rieures et une hypertension tardive peuvent appara\u00eetre. Les l\u00e9sions anatomopathologiques comportent trois types de l\u00e9sions: micro-angiopathie thrombotique exclusivement r\u00e9nale (10 cas); atteinte vasculaire diss\u00e9min\u00e9e de purpura thrombotique thrombocytop\u00e9nique (2 cas); enfin, n\u00e9crose corticale (7 cas) dont un cas avec l\u00e9sions vasculaires g\u00e9n\u00e9ralis\u00e9es. Les auteurs envisagent les corr\u00e9lations anatomo-cliniques et \u00e9volutives. Ils discutent des probl\u00e8mes nosologiques pos\u00e9s par les diverses l\u00e9sions anatomiques observ\u00e9es dans ce syndrome et sont partisans de I\u2019unit\u00e9 histo-pathologique du syndrome.<\/jats:p>","DOI":"10.1159\/000179580","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T09:18:13Z","timestamp":1227950293000},"page":"139-172","source":"Crossref","is-referenced-by-count":54,"title":["Le syndrome h\u00e9molytique et ur\u00e9mique de I\u2019enfant"],"prefix":"10.1159","author":[{"given":"Ren\u00e9e","family":"Habib","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Royer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,26]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/179580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000179580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:00:51Z","timestamp":1777647651000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000179580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000179580","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}