{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:04:05Z","timestamp":1777910645311,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>Nous avons group\u00e9 sous le nom de \u00abprot\u00e9inurie permanente isol\u00e9e\u00bb (PPI) les \u00e9tats pathologiques du rein dont le sympt\u00f4me unique est, d\u00e8s le debut, une prot\u00e9inurie permanente, toute autre manifestation \u00e9tant \u00e9limin\u00e9e par des conditions d\u2019observation d\u00e9finies avec pr\u00e9cision. L\u2019observation de 27 cas ainsi d\u00e9limit\u00e9s, et comportant une \u00e9tude histologique du rein, a \u00e9t\u00e9 poursuivie durant 5 \u00e0 28 ans. 1.II n\u2019a jamais \u00e9t\u00e9 constate I\u2019apparition ni d\u2019une h\u00e9maturie, ni d\u2019un syndrome n\u00e9phrotique, ni d\u2019une hypertension art\u00e9rielle permanente, ni d\u2019une alteration significative des vaisseaux des fonds d\u2019yeux. 2.Les fonctions r\u00e9nales sont rest\u00e9es normales dans 93% des cas; dans 2 observations une insumsance r\u00e9nale tardive s\u2019est constitu\u00e9e lentement, coincident une fois avec des grossesses r\u00e9p\u00e9t\u00e9es.3. Cette remarquable stabilit\u00e9 a \u00e9t\u00e9 constat\u00e9e m\u00eame lorsque le rein \u00e9tait le si\u00e9ge de l\u00e9sions histologiques importantes et m\u00eame quand l\u2019observation avait \u00e9t\u00e9 prolong\u00e9e durant de nombreuses ann\u00e9es (16 fois pendant plus de 8 ans, 1 fois jusqu\u2019\u00e0 28 ann\u00e9es). 4. Aucune cause n\u2019a pu \u00eatre incrimin\u00e9e par analogie avec les maladies r\u00e9nales r\u00e9pertori\u00e9es qui peuvent comporter une situation de prot\u00e9inurie isol\u00e9e passag\u00e8rement au cours de leur \u00e9volution.5. L\u2019\u00e9tat de PPI constitue un groupement nosologique dont les l\u00e9sions sont disparates. Son int\u00e9r\u00eat pratique ressortit \u00e0 son \u00e9volution, dont la stabilit\u00e9 est presque parfaite: fait remarquable dans le cadre de l\u00e9sions chroniques des glom\u00e9rules et des art\u00e8res du rein.<\/jats:p>","DOI":"10.1159\/000179749","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T09:18:13Z","timestamp":1227950293000},"page":"526-536","source":"Crossref","is-referenced-by-count":9,"title":["La stabilit\u00e9 evolutive des \u00e9tats de prot\u00e9inurie permanente isol\u00e9e"],"prefix":"10.1159","author":[{"given":"B.","family":"Antoine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Symvoulidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireille","family":"Dardenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,26]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/179749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000179749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:02:49Z","timestamp":1777647769000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000179749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000179749","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}