{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:31:28Z","timestamp":1777897888513,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res"],"abstract":"<jats:p>To demonstrate the effect of diazepam on serum growth hormone and prolactin levels in acromegaly, 7 acromegalics were studied. Every patient received 10 mg diazepam orally at zero time, and blood samples were obtained at 30-min intervals. The same patients also underwent a standard L-dopa test. They were given 500 mg L-dopa orally at zero time, and blood samples were obtained at 30-min intervals. The administration of diazepam did not induce any significant changes in either growth hormone or prolactin levels. On the other hand, the administration of L-dopa resulted in a significant decrease in growth hormone level from 74.25 \u00b1 22 ng\/ml (mean \u00b1 SEM) at zero time to a level of 52.8 \u00b1 21 and 58.77 \u00b1 22.7 ng\/ml at the 60- and 90-min intervals, respectively (p &lt; 0.05), and a significant decrease in prolactin level from a baseline of 56.18 \u00b1 17 to 25.5 \u00b1 8.4 ng\/ml (p &lt; 0.001) at the 60-min interval.It is suggested that the response of growth hormone to diazepam in acromegalics is qualitatively different from nonacromegalic controls.<\/jats:p>","DOI":"10.1159\/000179793","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T09:18:13Z","timestamp":1227950293000},"page":"186-190","source":"Crossref","is-referenced-by-count":1,"title":["Failure of Diazepam to Affect Growth Hormone and Prolactin in Acromegalics"],"prefix":"10.1159","author":[{"given":"Kamel M.","family":"Ajlouni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,26]]},"container-title":["Hormone Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000179793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:15:05Z","timestamp":1777626905000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000179793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000179793","archive":["Portico"],"relation":{},"ISSN":["0301-0163","1423-0046"],"issn-type":[{"value":"0301-0163","type":"print"},{"value":"1423-0046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}