{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:04:32Z","timestamp":1777910672965,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>La fonction r\u00e9nale, la composition du plasma et l\u2019excr\u00e9tion urinaire des principaux \u00e9lectrolytes ont \u00e9t\u00e9 \u00e9tudi\u00e9s chez 15 malades durant les trois jours qui suivent la lev\u00e9e d\u2019un obstacle de la voie excr\u00e9trice urinaire. La polyurie initiale peut \u00eatre tr\u00e8s importante et atteint un maximum de 16 ml\/min dans cette s\u00e9rie. Elle est de type osmotique et s\u2019abaisse r\u00e9guli\u00e8rement et rapidement chez 12 malades sur 15. L\u2019\u00e9l\u00e9vation secondaire de la diur\u00e8se chez 3 malades est en rapport avec un exc\u00e8s d\u2019apport. L\u2019osmolalit\u00e9 globale des urines est repr\u00e9sent\u00e9e par l\u2019osmolalit\u00e9 li\u00e9e \u00e0 l\u2019ur\u00e9e plus une constante qui repr\u00e9sente les concentrations \u00e9lectrolytiques remarquablement stables durant la p\u00e9riode consid\u00e9r\u00e9e. Une clearance de l\u2019eau libre positive a \u00e9t\u00e9 not\u00e9e de fa\u00e7on transitoire apr\u00e8s la lev\u00e9e de l\u2019obstacle chez 6 malades. Elle rel\u00e8ve de m\u00e9canismes \u00e9tiologiques multiples. Elle peut exister en l\u2019absence d\u2019une hypotonie plasmatique ou d\u2019apports hydriques excessifs. Le bilan hydrique et sodique est n\u00e9gatif chez tous les malades. La perte de poids a \u00e9t\u00e9 comprise entre 1 et 8,9 kg, sans signe clinique de d\u00e9shydratation. Le contr\u00f4le renal de l\u2019\u00e9quilibre acido-basique est diminu\u00e9 dans les m\u00e9mes proportions que les fonctions r\u00e9nales globales, mais l\u2019excr\u00e9tion des ions H+, ramen\u00e9e au millilitre de filtrat, para\u00eet s\u2019effectuer normalement. Une fuite urinaire importante des bicarbonates, en d\u00e9pit d\u2019une acidose plasmatique, a \u00e9t\u00e9 not\u00e9e dans un seul cas. Les faits observes permettent d\u2019\u00e9tablir un schema de traitement medical.<\/jats:p>","DOI":"10.1159\/000179828","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T09:18:13Z","timestamp":1227950293000},"page":"258-276","source":"Crossref","is-referenced-by-count":3,"title":["La lev\u00e9e d\u2019obstacle de la voie excr\u00e9trice urinaire"],"prefix":"10.1159","author":[{"given":"A.","family":"Chapman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Legrain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,26]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/179828","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000179828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:03:35Z","timestamp":1777647815000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000179828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000179828","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]}}}