{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:01:29Z","timestamp":1790895689832,"version":"4.1.0"},"reference-count":33,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T00:00:00Z","timestamp":1228780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T00:00:00Z","timestamp":1228780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>The effect of irbesartan on the expression of connective tissue growth factor (CTGF) and \u03b1-smooth-muscle actin (\u03b1-SMA) in the renal tubulointerstitium of diabetic rats was investigated in our study. Diabetes was induced in male Wistar rats by intraperitoneal administration of streptozotocin (STZ), 60 mg\u00b7kg&lt;sup&gt;\u20131&lt;\/sup&gt; body weight. The rats were then randomized to a diabetic group (DM) and an irbesartan therapy group (DM + Irb). The normal group (non-DM) rats were administered only citrate buffer. At the end of the 16th week, blood glucose, kidney weight\/body weight, urine albumin (UAlb) and creatinine clearance rate were determined. The renal histopathology was observed by light microscopy. Further biochemical analysis of CTGF and \u03b1-SMA was provided using real-time reverse transcription PCR, immunostaining and Western blotting techniques. Compared with the non-DM group, blood glucose, kidney weight\/body weight, UAlb, creatinine clearance and interstitial fibrotic lesions were increased in the DM group (p &lt; 0.01). Treatment with irbesartan improved these parameters except blood glucose. Compared with the non-DM group, expressions of CTGF and \u03b1-SMA in the renal tubulointerstitium were highly upregulated in the DM group (p &lt; 0.01). Administration of irbesartan prevented the high expressions of CTGF and \u03b1-SMA in renal tissue of diabetic rats. These results indicated that irbesartan can protect the kidney of STZ-diabetic rats by reducing the expression of CTGF and \u03b1-SMA in the renal tubulointerstitium.<\/jats:p>","DOI":"10.1159\/000180123","type":"journal-article","created":{"date-parts":[[2008,12,8]],"date-time":"2008-12-08T13:19:42Z","timestamp":1228742382000},"page":"80-87","source":"Crossref","is-referenced-by-count":10,"title":["Irbesartan Ameliorates Diabetic Nephropathy by Reducing the Expression of Connective Tissue Growth Factor and Alpha-Smooth-Muscle Actin in the Tubulointerstitium of Diabetic Rats"],"prefix":"10.1159","volume":"83","author":[{"given":"Xiaojun","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangju","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.2003-0018"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004110970"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000065640.77499.D7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199411103311907"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.45.4.522"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00301.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10157-005-0347-x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1042%2F0264-6021%3A3590077"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000130565.69170.85"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ackd.2005.01.008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F12.1.43"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007950200011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002180"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011489"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011303"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011161"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000017209"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00836.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200317913"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI200111951"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000033611.79556.AE"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2337%2Fdb06-1018"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00656.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12363389"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cellbi.2004.09.003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006050525"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.04-3217com"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg1036"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00271.x"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00416.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2963552-3"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159%2F000090504"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000031827.16102.C1"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/180123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/180123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:17:24Z","timestamp":1745453844000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000180123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,9]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000180123","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,9]]}}}