{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:07:27Z","timestamp":1777910847336,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T00:00:00Z","timestamp":1227830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T00:00:00Z","timestamp":1227830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>p-Aminohippurate (PAH) clearance studies were carried out on 15 patients suffering from renal disorders of different origin. In 6 patients the two kidneys were tested separately. It could be shown that in the human organism PAH undergoes partial metabolization resulting in the production of p-aminobenzoate (PAB), N-acetyl-PAH and N-acetyl-PAB. Distribution pattern of PAH and its metabolites is different in urine and blood samples: there is more N-acetyl-PAH in the urine than in the blood. Benzoates make up to 75% of all aromatic amines present in the renal vein. Since routine laboratory analysis does not detect the metabolites, the theoretical basis of applicability of PAH as a clearance substance is invalidated. Re-absorbed benzoates may be one of the causes of incomplete extraction ratio of PAH. Renal artery stenosis reduces the capability of the human kidney to N-acetylate aromatic amines.<\/jats:p>","DOI":"10.1159\/000180386","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T09:20:02Z","timestamp":1227950402000},"page":"138-144","source":"Crossref","is-referenced-by-count":9,"title":["Metabolism of p-Aminohippurate and its Relevance in Man"],"prefix":"10.1159","author":[{"given":"J.","family":"Girndt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"M\u00e1lyusz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.W.","family":"Rumpf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Neubaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Scheler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,28]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/180386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000180386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:08:11Z","timestamp":1777648091000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000180386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000180386","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,28]]}}}