{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:34:44Z","timestamp":1773552884460,"version":"3.50.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Surg"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The aim of this study was to elucidate the natural history of appendicitis. &lt;i&gt;Methods:&lt;\/i&gt; Data was collected prospectively from consecutive patients admitted to hospital for acute abdominal pain. The degree of appendiceal inflammation in relation to preoperative duration of pain was analysed. &lt;i&gt;Results:&lt;\/i&gt; The study comprised 253 patients operated on for acute appendicitis that could recall the onset of abdominal pain. There was a longer duration of pre-hospital pain in patients, irrespective of age, with perforated appendicitis compared to patients with phlegmonous or gangrenous appendicitis (p &lt; 0.001). In the multivariate analysis, patient age and preoperative duration of pain were independent risk factors for perforation. &lt;i&gt;Conclusion:&lt;\/i&gt; Patient delay in presentation is the predominant factor determining the incidence of complicated appendicitis, and this delay is not influenced by age or gender.<\/jats:p>","DOI":"10.1159\/000180451","type":"journal-article","created":{"date-parts":[[2008,12,8]],"date-time":"2008-12-08T13:19:42Z","timestamp":1228742382000},"page":"394-399","source":"Crossref","is-referenced-by-count":45,"title":["Impact of Time in the Development of Acute Appendicitis"],"prefix":"10.1159","volume":"25","author":[{"given":"L.-E.","family":"Hansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Laurell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Gunnarsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199703000-00003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-6757%2896%2990074-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-199503000-00010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1445-1433.2004.02785.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F110241501316914902"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002689900235"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fajem.2000.7323"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2896%2900011-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199801153380301"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1089%2F109629603322419562"}],"container-title":["Digestive Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/180451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/180451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:20:30Z","timestamp":1745454030000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000180451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000180451","archive":["Portico"],"relation":{},"ISSN":["0253-4886","1421-9883"],"issn-type":[{"value":"0253-4886","type":"print"},{"value":"1421-9883","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}