{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:33:59Z","timestamp":1777898039950,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T00:00:00Z","timestamp":1227830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T00:00:00Z","timestamp":1227830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res"],"abstract":"<jats:p>High-resolution computed tomography (HR-CT) of the hypothalamo-pituitary region was performed in 26 consecutive children presenting with growth hormone deficiency (GHD) at one clinic. 58% had an empty sella turcica (ES) and 42% a full sella turcica (FS). There was no difference between the ES and FS groups for mean ( \u00b1 95% confidence limits) presentation age (ES 6.7 ( \u00b1 1.8) years, FS 5.6 ( \u00b1 2.2) years), height standard deviation score (SDS) (ES -3.9 ( \u00b1 0.8), FS -3.3 ( \u00b1 0.5)) nor head circumference SDS (ES -1.9 ( \u00b1 1.1), FS -0.7 ( \u00b1 1.1)). There were significant associations between the ES group and a history of adverse perinatal events (p &lt; 0.001) and multiple pituitary deficiency (p = 0.014). Growth hormone response to an acute growth hormone releasing factor test showed no association with HR-CT diagnosis. Sella turcica volumes were calculated from the HR-CT scans. All sella volumes were small; mean SDS for height was -2.6 ( \u00b1 0.2). There was no difference in sella volume SDS between the ES and FS groups (ES -2.9 ( \u00b1 0.3), FS -2.5 ( \u00b1 0.4)). Adverse perinatal events may cause an ES and GHD by compromising the blood supply to the pituitary gland or infundibulum.<\/jats:p>","DOI":"10.1159\/000180918","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T09:20:02Z","timestamp":1227950402000},"page":"5-12","source":"Crossref","is-referenced-by-count":19,"title":["Association of Adverse Perinatal Events with an Empty Sella turcica in Children with Growth Hormone Deficiency"],"prefix":"10.1159","author":[{"given":"Robert","family":"Surtees","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Shalet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,28]]},"container-title":["Hormone Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000180918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:18:31Z","timestamp":1777627111000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000180918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000180918","archive":["Portico"],"relation":{},"ISSN":["0301-0163","1423-0046"],"issn-type":[{"value":"0301-0163","type":"print"},{"value":"1423-0046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,28]]}}}