{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:34:19Z","timestamp":1777898059130,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T00:00:00Z","timestamp":1227830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,11,28]],"date-time":"2008-11-28T00:00:00Z","timestamp":1227830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res"],"abstract":"<jats:p>To test whether chronic thyroid hormone excess influences the hypothalamic-pituitary-testicular axis, 8 hyperthyroid men were given two identical intravenous GnRH tests. The first test was performed before any treatment had been instituted, the second 6\u201313 months later, when medical treatment had made the patients euthyroid. Although basal serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone (T) levels were of similar magnitudes before and after the medical treatment, LH and FSH responsiveness to gonadotropin-releasing hormone (GnRH), as reflected by the hormone incremental areas (U\/l \u00d7 min), were significantly larger in the thyrotoxic state compared with the euthyroid state (LH incremental areas: 3,999 \u00b1 665 vs. 2,640 \u00b1 430, p &lt; 0.02; FSH incremental areas: 825 \u00b1 193 vs. 542 \u00b1 98, p &lt; 0.05). Furthermore, serum T increased significantly in response to GnRH when the patients were hyperthyroid (T incremental area: 162 \u00b1 51 p &lt; 0.02), but failed to do so when they were euthyroid (T incremental area: 92 \u00b1 53, NS). These results imply that chronic thyroid hormone excess makes the pituitary gonadotrophs \u2018hypersensitive\u2019 to exogenous GnRH. This may in turn explain why human Ley dig cells respond more powerful to exogenous GnRH in thyrotoxic patients than in euthyroid subjects.<\/jats:p>","DOI":"10.1159\/000181000","type":"journal-article","created":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T08:16:09Z","timestamp":1228119369000},"page":"185-190","source":"Crossref","is-referenced-by-count":24,"title":["Hypothalamic-Pituitary-Testicular Axis in Patients with Hyperthyroidism"],"prefix":"10.1159","author":[{"given":"Sven","family":"R\u00f6jdmark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Kallner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,11,28]]},"container-title":["Hormone Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000181000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:19:15Z","timestamp":1777627155000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000181000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000181000","archive":["Portico"],"relation":{},"ISSN":["0301-0163","1423-0046"],"issn-type":[{"value":"0301-0163","type":"print"},{"value":"1423-0046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,28]]}}}