{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:11:54Z","timestamp":1777911114476,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:00:00Z","timestamp":1228176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:00:00Z","timestamp":1228176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>Cardiac output (CO) and renal blood flow (RBF) were simultaneously evaluated (microsphere method) in awake rats, 3, 6, and 24 h after induction of acute renal failure by mercuric chloride (HgCl&lt;sub&gt;2&lt;\/sub&gt;; 4.7 mg\/kg body weight). 3 h after injection of HgCl&lt;sub&gt;2&lt;\/sub&gt; CO and RBF decreased to 77 and 72% of respective control values of 32.0 \u00b1 2.4 and 4.65 \u00b1 0.44 ml\/min\/100 g. Renal vascular resistance (RVR) and total peripheral resistance (TPR) were significantly increased compared to control at this time. Similar results were observed 6 h after administration of HgCl&lt;sub&gt;2&lt;\/sub&gt;. Volume expansion with plasma (2% of body weight) restored CO, RBF, TPR, and RVR to normal 3 h after injection of HgCl&lt;sub&gt;2&lt;\/sub&gt;. Despite significantly elevated blood urea nitrogen 24 h after injection of HgCl&lt;sub&gt;2&lt;\/sub&gt; (103.7 mg%), all hemodynamic parameters were within control range. Plasma volume was normal 3 h after HgCl&lt;sub&gt;2&lt;\/sub&gt; but was significantly elevated compared to control 24 h after HgCl&lt;sub&gt;2&lt;\/sub&gt; (4.73 vs. 3.92 ml\/l00 g, p &lt; 0.01). These findings indicate that factors other than preferential renal vasoconstriction may be involved in the transient renal ischemia of HgCl&lt;sub&gt;2&lt;\/sub&gt;-induced acute renal failure.<\/jats:p>","DOI":"10.1159\/000181377","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T16:39:41Z","timestamp":1228322381000},"page":"100-106","source":"Crossref","is-referenced-by-count":7,"title":["Systemic Hemodynamics in Nephrotoxic Acute Renal Failure"],"prefix":"10.1159","author":[{"given":"Theodore W.","family":"Kurtz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen H.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,2]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/181377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000181377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:15:37Z","timestamp":1777648537000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000181377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000181377","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,2]]}}}