{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:35:55Z","timestamp":1777898155728,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:00:00Z","timestamp":1228176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:00:00Z","timestamp":1228176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res"],"abstract":"<jats:p>This study examined the effect of 17\u03b2-estradiol (E&lt;sub&gt;2&lt;\/sub&gt;) on basal and luteinizing hormone (LH)-releasing hormone (LHRH)-stimulated gonadotropin secretion in 9 patients with Klinefelter\u2019s syndrome. Intramuscular injection of E&lt;sub&gt;2&lt;\/sub&gt; (10 \u00b5g\/kg\/day during 5 days) induced a rapid decrease in follicle-stimulating hormone (FSH) and LH levels. The maximum suppression was observed on day 7 (D7) for FSH [median 9.7 mlU\/ml (range 4.6-37.8) vs. 21.7 mlU\/ml (range 12.2-56.9)] and on D2 for LH [median 13.6 mlU\/ml (range 6.8-25.2) vs. 21.2 mlU\/ml (range 13-54.7)]. E&lt;sub&gt;2&lt;\/sub&gt; concentrations rose and reached their peak values on D3 [median 723 pmol\/l (range 517-1,247.8) vs. 110.1 pmol\/l (range 68.6-227.5) on DO]. These changes were followed by a subsequent rise in LH on D4 [36.7 mlU\/ml (range 19.4-77.7)]. LH response to LHRH was higher during E&lt;sub&gt;2&lt;\/sub&gt; treatment: median value of absolute peaks: 156.3 mlU\/ml (range 56.7-188.6) on D4 vs. 64 mlU\/ml (range 38.9-131) on DO. These results demonstrate the presence of a positive feedback in patients with Klinefelter\u2019s syndrome.<\/jats:p>","DOI":"10.1159\/000181526","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T16:39:41Z","timestamp":1228322381000},"page":"244-247","source":"Crossref","is-referenced-by-count":4,"title":["Presence of Positive Feedback in Males with Klinefelter\u2019s Syndrome"],"prefix":"10.1159","author":[{"given":"C.","family":"Boucekkine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Semrouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,2]]},"container-title":["Hormone Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000181526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:22:05Z","timestamp":1777627325000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000181526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000181526","archive":["Portico"],"relation":{},"ISSN":["0301-0163","1423-0046"],"issn-type":[{"value":"0301-0163","type":"print"},{"value":"1423-0046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,2]]}}}