{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:39:16Z","timestamp":1789007956933,"version":"build-2803163510"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T00:00:00Z","timestamp":1228521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T00:00:00Z","timestamp":1228521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Recurrent and painful genital ulcers are the hallmark of Beh\u00e7et\u2019s disease. &lt;i&gt;Objective:&lt;\/i&gt; To determine the efficacy of pimecrolimus (PIM) cream on the pain and healing time of genital ulcers. &lt;i&gt;Methods:&lt;\/i&gt; A total of 76 patients were randomized to either receive PIM cream plus colchicine (COL) tablets (1\u20132 g\/day) or COL tablets (1\u20132 g\/day) alone for 1 month. Clinical evaluations were performed in 68 patients at the baseline and on the 3rd, 7th, 10th, 14th and 28th days of treatment. Also, genital ulcer pain was evaluated using a verbal pain score at each visit. Safety was monitored through adverse event reporting and laboratory tests. &lt;i&gt;Results:&lt;\/i&gt; The mean healing time of genital ulcers was shorter in the PIM + COL group (4.2 \u00b1 1.5 days) than the COL group (4.7 \u00b1 1.8 days), without statistical significance (p = 0.399). Visual analog scale scores decreased in both groups significantly. Neither of the treatment modalities was found to be superior to the other; however, pain was relieved in 4.2 \u00b1 0.5 days in PIM + COL group and in 5.5 \u00b1 1.2 days in COL group in the intention to treat population (p = 0.023). Observed adverse events were transient. &lt;i&gt;Conclusion:&lt;\/i&gt; Compared to COL alone, COL + PIM cream shortens the pain duration without any significant effect on healing time.<\/jats:p>","DOI":"10.1159\/000182257","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T14:03:17Z","timestamp":1228485797000},"page":"140-145","source":"Crossref","is-referenced-by-count":27,"title":["Randomized Trial of Pimecrolimus Cream plus Colchicine Tablets versus Colchicine Tablets in the Treatment of Genital Ulcers in Beh\u00e7et\u2019s Disease"],"prefix":"10.1159","volume":"218","author":[{"given":"Osman","family":"K\u00f6se","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Din\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"\u015eim\u015fek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2007.08116.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Frheumatology%2Fkel329"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fncprheum0436"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-3083.2001.00251.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F01.rhu.0000249894.03016.de"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.135.5.529"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28200111%2944%3A11%3C2686%3A%3AAID-ART448%3E3.0.CO%3B2-H"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000096195"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000095289"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000102119"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2006.02859.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000093860"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000106578"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000100879"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/182257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/182257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:08:22Z","timestamp":1745453302000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000182257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,6]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000182257","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,6]]}}}