{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:15:38Z","timestamp":1773090938678,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T00:00:00Z","timestamp":1228521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,12,6]],"date-time":"2008-12-06T00:00:00Z","timestamp":1228521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Necrobiosis lipoidica (NL) is a granulomatous skin disease of unknown origin, and no reliably effective treatment option exists to handle this often disfiguring disease. Recently, a patient with long-lasting NL was reported to be cured by topical photodynamic therapy (PDT). &lt;i&gt;Objective:&lt;\/i&gt; To evaluate the overall potential of PDT in the treatment of NL on the lower legs. &lt;i&gt;Methods:&lt;\/i&gt; Retrospective study of 18 patients (aged 16\u201362 years) from 3 European university departments of dermatology treated with PDT for NL. Methyl aminolevulinate or 5-aminolevulinic acid were used as topically applied photosensitizers. Illumination followed with red light-emitting diode light. &lt;i&gt;Results:&lt;\/i&gt;Complete response was seen in 1\/18 patients after 9 PDT cycles, and partial response in 6\/18 patients (2\u201314 PDT cycles) giving an overall response rate of 39% (7\/18). &lt;i&gt;Conclusion:&lt;\/i&gt; Although almost 40% of the cases showed some degree of response, PDT cannot currently be recommended as first-line therapy of NL. Subpopulations of therapy-resistant NL patients may, however, benefit from PDT.<\/jats:p>","DOI":"10.1159\/000182259","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T14:03:17Z","timestamp":1228485797000},"page":"136-139","source":"Crossref","is-referenced-by-count":48,"title":["Photodynamic Therapy of Necrobiosis Lipoidica \u2013 A Multicenter Study of 18 Patients"],"prefix":"10.1159","volume":"218","author":[{"given":"C.","family":"Berking","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hegyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Arenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ruzicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.B.E.","family":"Jemec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2808%2980961-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0733-8635%2802%2900018-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1992.tb00097.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1999.03119.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2887%2980338-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.04856.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2802%2970230-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000068465"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.142.12.1548"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Flsm.20337"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1346-8138.2006.00150.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.140.10.1287"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000106577"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/182259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/182259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:08:25Z","timestamp":1745453305000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000182259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,6]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000182259","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,6]]}}}