{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:18:03Z","timestamp":1777911483866,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T00:00:00Z","timestamp":1228262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T00:00:00Z","timestamp":1228262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>The renal function of 7 patients with cor pulmonale and secondary polycythaemia was studied by clearance methods. Their haematocrit (Hct) was initially 62 \u00b1 6% (mean \u00b1 SD). Their effective renal plasma flow rates (RPF) were reduced and filtration fractions (FF) increased. They were restudied 5\u20137 days after Hct reduction to 49 \u00b1 5%. There were no significant changes in glomerular filtration rate (GFR), RPF, FF, effective renal blood flow (RBF) or body weight. However, 5 of 7 patients had a reduction in FF and a fall in body weight. Serial measurements in one patient demonstrated that immediately following the reduction in Hct there was an increase in RPF and a fall in FF, but these reverted to previous levels within 1 week. Overall, a positive correlation was obtained between changes in body weight and FF (r = 0.85, n = 7, p &lt; 0.015). Polycythaemia is only one factor contributing to a low RPF and high FF in patients with cor pulmonale; reduction of the Hct reduces the FF in some patients and leads to a diuresis which may be beneficial in those with fluid retention.<\/jats:p>","DOI":"10.1159\/000182456","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T16:39:41Z","timestamp":1228322381000},"page":"173-177","source":"Crossref","is-referenced-by-count":11,"title":["Renal Function in Patients with Chronic Hypoxaemia and Cor Pulmonale Following Reversal of Polycythaemia"],"prefix":"10.1159","author":[{"given":"C.S.","family":"Wilcox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Payne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.D.W.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,3]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/182456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000182456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:26:42Z","timestamp":1777649202000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000182456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000182456","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,3]]}}}