{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:20:02Z","timestamp":1792084802247,"version":"4.4.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T00:00:00Z","timestamp":1228262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T00:00:00Z","timestamp":1228262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res"],"abstract":"<jats:p>Depression is a common, life-threatening complication of Cushing\u2019s syndrome and may occur in several other endocrine disorders. It is not clear, however, whether distinct features pertain to hypercortisohsm. We studied depression in Cushing\u2019s syndrome differentiating pituitary-dependent and pituitary-independent forms, its incidence compared to Graves\u2019 disease, and its appearance in the prodromal phase of both conditions. To 66 consecutive patients with Cushing\u2019s syndrome and 70 with Graves\u2019 disease, after treatment, a semistructured interview for depressive symptoms based on Paykel\u2019s clinical interview for depression was administered. In Cushing\u2019s syndrome, the response of depression to normalization of urinary cortisol levels was evaluated by Kellner\u2019s global rating method. There was a significant difference in the occurrence of depression (p &lt; 0.001) between Cushing\u2019s syndrome (62%) and Graves\u2019 disease (23%). Depression appeared in the prodromal phase in 27% of patients with Cushing\u2019s syndrome and in 14% of those with Graves\u2019 disease, but the difference was not significant. In Cushing\u2019s syndrome, there were no significant differences in depression between patients with pituitary-dependent (n = 41) and pituitary-independent (n = 20) forms, or in their response to treatment. About 70% of patients fully recovered from their depression, whereas there was no substantial change in the others and even worsening in 2. Our findings in Cushing\u2019s syndrome and Graves\u2019 disease are in agreement with previous investigations using specific diagnostic criteria for depression. We found a tendency for this symptom to manifest in the prodromal phase of both illnesses. An endocrine etiology should be, therefore, considered in depressed patients not responding to standard psychiatric treatment.<\/jats:p>","DOI":"10.1159\/000182736","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T16:39:41Z","timestamp":1228322381000},"page":"202-206","source":"Crossref","is-referenced-by-count":64,"title":["Course of Depression in Cushing\u2019s Syndrome: Response to Treatment and Comparison with Graves\u2019 Disease"],"prefix":"10.1159","author":[{"given":"Nicoletta","family":"Sonino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni A.","family":"Fava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera","family":"Belluardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Girelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Boscaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,12,3]]},"container-title":["Hormone Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000182736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:27:21Z","timestamp":1777627641000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000182736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,3]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000182736","archive":["Portico"],"relation":{},"ISSN":["0301-0163","1423-0046"],"issn-type":[{"value":"0301-0163","type":"print"},{"value":"1423-0046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,3]]}}}