{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:34:52Z","timestamp":1778607292237,"version":"3.51.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The existence of antineutrophil cytoplasmic antibody (ANCA)-positive pulmonary fibrosis (PF) has recently been recognized. &lt;i&gt;Objectives:&lt;\/i&gt; The aim of this study was to clarify whether there is any difference in the clinical features between ANCA-positive PF and ANCA-negative PF. &lt;i&gt;Methods:&lt;\/i&gt; A retrospective study was carried out on 53 patients with idiopathic PF whose myeloperoxidase (MPO)- and proteinase 3 (PR3)-ANCA levels were measured. After dividing the patients into ANCA-positive and ANCA-negative PF, we compared their symptoms, pulmonary function tests, chest CT findings, bronchoalveolar lavage findings, the effects of therapy and survival rates. &lt;i&gt;Results:&lt;\/i&gt; 17 of the 53 patients with idiopathic PF were MPO-ANCA-positive, 2 were PR3-ANCA-positive and 34 were negative for both ANCA types. Lactate dehydrogenase was lower in ANCA-positive PF than in ANCA-negative PF. However, there was no significant difference in the symptoms, lung function tests, CT findings and bronchoalveolar lavage findings. Corticosteroid therapy tended to be more effective in ANCA-positive PF, but the overall survival rate in ANCA-positive PF was not different from that in ANCA-negative PF. However, the low-titer (&lt;50 EU) group showed better survival than the high-titer (\u226550 EU) group in ANCA-positive PF. ANCA titers of the patients who developed microscopic polyangiitis were higher than of those who did not develop it in ANCA-positive PF. &lt;i&gt;Conclusions:&lt;\/i&gt; Our studies showed little difference in the clinical features between ANCA-positive and ANCA-negative PF. However, it may be important to measure ANCA when idiopathic PF is diagnosed, because a high titer of ANCA suggests a poor prognosis and the association with microscopic polyangiitis.<\/jats:p>","DOI":"10.1159\/000183754","type":"journal-article","created":{"date-parts":[[2008,12,10]],"date-time":"2008-12-10T15:51:15Z","timestamp":1228924275000},"page":"407-415","source":"Crossref","is-referenced-by-count":71,"title":["A Comparison of the Clinical Features of ANCA-Positive and ANCA-Negative Idiopathic Pulmonary Fibrosis Patients"],"prefix":"10.1159","volume":"77","author":[{"given":"Tomoko","family":"Nozu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tamaoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.285.6342.606"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.171.1.357"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198806233182504"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2885%2991147-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.149.11.2461"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2806%2969114-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.110.2.357"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000089656"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2006.06.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1843.2006.00834.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1843.2004.00581.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F01.rct.0000135280.79012.c7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.98.12051010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.110.2.357"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.290.6484.1775"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000106848"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.1.297"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1513%2Fpats.200511-120JH"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.129.2.452"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa020286"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/183754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/183754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:26:16Z","timestamp":1745454376000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000183754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,11]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000183754","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,11]]}}}