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Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Eine fr\u00fche intrauterine fetale (Fehl-)Programmierung hat nicht nur Auswirkungen auf die kardiovaskul\u00e4re und metabolische Regulation im sp\u00e4teren Leben, auch die reproduktive Funktion kann dadurch beeinflusst werden. Eine intrauterine Wachstumsretardierung kann mit einer vorzeitigen Reifung der gonadalen Funktion und einer Vorverlegung der Pubert\u00e4t und des Menarchealters verbunden sein. Sowohl die Entwicklung von Ovarien und \u00e4usseren Genitalien selbst als auch die neurodendokrine Regulation der hypothalamisch-hypophys\u00e4r-ovariellen Achse werden insbesondere durch pr\u00e4natale Androgeneffekte ung\u00fcnstig beeinflusst, sodass im sp\u00e4teren Leben h\u00e4ufiger ein polyzystisches Ovarsyndrom mit Hyperandrogen\u00e4mie und Ovulationsst\u00f6rungen auftritt. Diese tierexperimentell klar nachweisbaren Zusammenh\u00e4nge bed\u00fcrfen jedoch noch weiterer Belege durch epidemiologische und klinische Untersuchungen am Menschen.<\/jats:p>","DOI":"10.1159\/000184440","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T06:50:30Z","timestamp":1233989430000},"page":"2-7","source":"Crossref","is-referenced-by-count":1,"title":["Intrauterine Programmierung reproduktiver Funktionen \u2013 ein tragf\u00e4higes Konzept?"],"prefix":"10.1159","volume":"49","author":[{"given":"Ekkehard","family":"Schleussner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1042%2FCS19980019"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tem.2005.11.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fbeem.2002.0181"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.107.4.e59"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.11.3945"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1754.2002.00793.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1982.tb09490.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2105%2FAJPH.87.12.1962"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1378"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.22004"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000058108"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1490425"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-3782%2897%2900073-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067%2Fmpd.2002.126300"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.2001.01399.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.7.3391"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.7.2624"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200005000-00003"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.76.6.1599"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeg351"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199509283331307"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.140.12.5797"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdmi013"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.3.1206"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2897%2981873-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2004-1444"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra022784"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.79.5.1328"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-1005"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F17.10.2573"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2757"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159%2F000299482"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2906062-5"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeg409"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2006.03.013"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-0336"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/184440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/184440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:34:13Z","timestamp":1745454853000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000184440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000184440","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"type":"print","value":"1018-8843"},{"type":"electronic","value":"1423-0011"}],"subject":[],"published":{"date-parts":[[2009]]}}}