{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T10:22:53Z","timestamp":1748254973202,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>Geh\u00e4uft ist nach intrauteriner Wachstumsrestriktion (IUGR) ein Auftreten von Nierenfunktionsst\u00f6rungen im sp\u00e4teren Leben zu beobachten. Hierf\u00fcr k\u00f6nnen 2 prinzipielle Entstehungsmodelle beobachtet werden: Einerseits ist nach IUGR eine h\u00f6here Pr\u00e4valenz von Hypertonie und Diabetes mellitus vom Typ 2 belegt \u2013 beide Erkrankungen pr\u00e4disponieren ihrerseits f\u00fcr die Entwicklung einer chronischen Niereninsuffizienz im Erwachsenenalter. Andererseits werden bei einem niedrigen Geburtsgewicht prim\u00e4r renale Ver\u00e4nderungen beobachtet: So ist beispielsweise die Zahl funktionsf\u00e4higer Nephrone reduziert. Dies kann langfristig ebenso einen vorzeitigen renalen Funktionsverlust beg\u00fcnstigen. Zudem ist bereits im Kindesalter ein schwererer Verlauf von glomerul\u00e4ren Erkrankungen nach IUGR zu beobachten. So findet sich beim kindlichen nephrotischen Syndrom ein prognostisch ung\u00fcnstigerer Verlauf und bei der IgA-Nephropathie des Kindes ein h\u00f6herer Anteil an sklerosierten Glomeruli. Tierexperimentell l\u00e4sst sich belegen, dass eine erh\u00f6hte Entz\u00fcndungsaktivit\u00e4t und verminderte Regenerationsf\u00e4higkeit pathogenetisch zugrunde liegen. Auch zeigt sich, dass nicht nur pr\u00e4natale, sondern auch postnatale Einfl\u00fcsse, wie zum Beispiel eine postnatale Hyperalimentation, die Manifestation der renalen Sch\u00e4digung beg\u00fcnstigen.<\/jats:p>","DOI":"10.1159\/000184441","type":"journal-article","created":{"date-parts":[[2009,2,4]],"date-time":"2009-02-04T13:47:13Z","timestamp":1233755233000},"page":"8-12","source":"Crossref","is-referenced-by-count":2,"title":["Intrauterine Wachstumsrestriktion und Nierenfunktion \u2013 ein Langzeitproblem?"],"prefix":"10.1159","volume":"49","author":[{"given":"J\u00f6rg","family":"D\u00f6tsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Plank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl222"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2805%2980005-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1998.00121.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-007-0597-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2892%2991341-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000044987"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.160.10.1472"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1524-6175.2001.00828.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00018.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa020549"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ackd.2008.01.003"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5001966"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.00484.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000065275"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004100875"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00158.2006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-004-1643-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000054212.23528.B2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1042%2FCS20070113"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.617811"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00674.x"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/184441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/184441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:34:13Z","timestamp":1745454853000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000184441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000184441","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"type":"print","value":"1018-8843"},{"type":"electronic","value":"1423-0011"}],"subject":[],"published":{"date-parts":[[2009]]}}}