{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T17:43:10Z","timestamp":1777916590162,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T00:00:00Z","timestamp":1228435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T00:00:00Z","timestamp":1228435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>In 13 essential hypertensives, 15 renal hypertensives, 16 patients with phaeochromocytoma, 6 patients with renal artery stenosis and in 21 normotensive controls the Ca2+ and K+ content in the ashed material from red blood cells was determined by flame photometry. Furthermore, intracellular K+ concentration was measured in the haemolysate. The ratio between Ca2+ and K+ concentration in ashed red blood cells (Ca&lt;sub&gt;i&lt;\/sub&gt;2 \/K&lt;sub&gt;i&lt;\/sub&gt;+) was 2.07 \u00b1 0.9110\u20133 in normotensives, 4.58 \u00b1 1.68 10-3 in essential hypertensives (p &lt; 0.01), 3.13 \u00b1 1.90 10\u20133 in renal hypertensives (p &lt; 0.05), 2.15 \u00b1 1.62 in patients with phaeochromocytoma and in patients with renal artery stenosis 2.25 \u00b1 1.25. Intracellular K+ concentration was 94.3 \u00b1 3.1 \u03bcmol\/l in normotensives, 94.7 \u00b1 3.8 \u03bcmol\/l in essential hypertensives and 93.8 \u00b1 3.9 \u03bcmol\/l in renal hypertensives, 198.2 \u00b1 149.1 \u03bcmol\/l in patients with phaeochromocytoma and 201.1 \u00b1 139.1 \u03bcmol\/l in patients with renal artery stenosis. Therefore, intracellular total Ca2+ concentrations is concluded to be increased in red blood cells from essential hypertensives and, to a lesser extent, in those from renal hypertensives. The method to determined Ca&lt;sub&gt;i&lt;\/sub&gt;2\/K&lt;sub&gt;i&lt;\/sub&gt;+ in the red blood cells may thus be suitable to assess cellular Ca2+ content in hypertension.<\/jats:p>","DOI":"10.1159\/000184575","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T06:03:14Z","timestamp":1229320994000},"page":"146-148","source":"Crossref","is-referenced-by-count":1,"title":["Intracellular Calcium in Secondary Hypertension"],"prefix":"10.1159","author":[{"given":"Claus","family":"Spieker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Zidek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Losse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,5]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/184575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000184575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:52:01Z","timestamp":1777657921000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000184575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000184575","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,5]]}}}