{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:40:49Z","timestamp":1777898449835,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T00:00:00Z","timestamp":1228435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T00:00:00Z","timestamp":1228435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res"],"abstract":"<jats:p>To determine the final height of patients with precocious pubery treated with medroxyprogesterone acetate (MPA; 150 mg every week) for a period &gt; 1 year (mean \u00b1 SD = 3.24 \u00b1 1.85 years), data from a group of 26 girls were analyzed. The attained final height was 155.6 \u00b1 8.06 cm ( 1.1 SD of the normal population). In a group of 8 untreated girls with precocious puberty, adult height was 149.2 \u00b1 5.07 (-2.16 SD, p &lt; 0.02). In 9 patients in whom treatment was stopped at a bone age \u2264 12 years, final height was 159.2 \u00b1 10.05 cm, while in 16 girls who had a bone age &gt; 12 years at the end of treatment, the final height was 153.03 \u00b1 6.28 cm. Our data demonstrate the effectiveness of MPA treatment on ultimate height. The better height observed in those patients who stopped treatment with a bone age &lt; 12 years suggests the advantage of discontinuing therapy before reaching a more advanced degree of skeletal maturation.<\/jats:p>","DOI":"10.1159\/000184583","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T06:03:14Z","timestamp":1229320994000},"page":"12-16","source":"Crossref","is-referenced-by-count":1,"title":["Bone Age at Discontinuation of Medroxyprogesterone Acetate Therapy in Girls with Precocious Puberty: Effect on Final Height"],"prefix":"10.1159","author":[{"given":"E.","family":"Boulgourdjian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.E.","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bergad\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,5]]},"container-title":["Hormone Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000184583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:30:58Z","timestamp":1777627858000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000184583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,5]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000184583","archive":["Portico"],"relation":{},"ISSN":["0301-0163","1423-0046"],"issn-type":[{"value":"0301-0163","type":"print"},{"value":"1423-0046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,5]]}}}