{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:53:31Z","timestamp":1781049211046,"version":"3.54.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; N-terminal pro-brain natriuretic peptide (NT-proBNP) has been demonstrated to be associated with cardiovascular disease (CVD) and mortality in end-stage renal disease patients. We hypothesized that common confounders, such as protein-energy wasting (PEW) and inflammation could modulate this relationship. &lt;i&gt;Methods:&lt;\/i&gt; NT-proBNP was measured in 222 prevalent hemodialysis (HD) patients (55.4% male, mean age 66 years, range 51\u201374) using commercial ELISA. Levels were related to clinical characteristics, biochemical markers and survival. &lt;i&gt;Results:&lt;\/i&gt; NT-proBNP levels were positively associated with IL-6 (\u03c1 = 0.37, p &lt;0.001) and C-reactive protein (\u03c1 = 0.25, p &lt;0.001), but negatively associated with serum IGF-1 (\u03c1 = \u20130.34, p &lt; 0.001), handgrip strength (\u03c1 = \u20130.30, p &lt;0.001) and body weight (\u03c1 = \u20130.20, p &lt; 0.001). In multivariate analysis, an NT-proBNP level above the cutoff of the receiver-operating curve (9,761 pg\/ml) was associated with PEW (odds ratio = 2.30, p = 0.008) even following adjustment for age, dialysis vintage, inflammation and the Davies score. As expected, NT-proBNP predicted clinical CVD (odds ratio = 1.90, p = 0.05) and all-cause mortality (Cox regression hazard ratio = 1.57, p = 0.03) also after adjustment for confounders. Patients with an NT-proBNP above the cutoff also exhibited a higher mortality (Kaplan-Meier \u03c7&lt;sup&gt;2&lt;\/sup&gt; = 13.95, p &lt; 0.001). &lt;i&gt;Conclusion:&lt;\/i&gt; We demonstrate a novel association between NT-proBNP and PEW, which may be part of the explanation for the strong links between NT-proBNP and mortality in HD patients.<\/jats:p>","DOI":"10.1159\/000185628","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T15:27:44Z","timestamp":1229095664000},"page":"516-523","source":"Crossref","is-referenced-by-count":19,"title":["N-Terminal Pro-Brain Natriuretic Peptide Independently Predicts Protein Energy Wasting and Is Associated with All-Cause Mortality in Prevalent HD Patients"],"prefix":"10.1159","volume":"29","author":[{"given":"Qunying","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"B\u00e1r\u00e1ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul 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