{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:59:17Z","timestamp":1778853557426,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>The kidney involvement in leptospirosis appears to be a special form of acute renal failure due to a higher frequency of polyuric forms and the presence of hypokalemia with an elevated urinary fractional excretion of potassium. Using a clearance technique, we detected higher fractional urinary potassium excretion in leptospirotic guinea pigs (26.5 \u00b1 4.7%) than in normal animals (14.1 \u00b1 2,8%, p &lt; 0.05). After blocking distal NaCl reabsorption with furosemide, it was observed that in leptospirotic animals both fractional sodium excretion (40.0 \u00b1 7.4%) and fractional potassium excretion (136.3 \u00b1 32.7%) were higher than in normal animals (20.4 \u00b1 3.8%, p &lt; 0.05, and 43.6 \u00b1 9.0%, p &lt; 0.05, respectively). Microperfusion studies showed that the normal and leptospirotic medullary thick ascending limb had both identical transepithelial potential difference (+ 3.7 \u00b1 0.4 vs. 3.9 \u00b1 0.2 mV) and relative sodium-to-chloride permeability. The same technique showed that the osmotic water permeability (P&lt;sub&gt;osm&lt;\/sub&gt;; 0.9 \u00b1 0.4 \u00d7 10-5 cm\/s \u00b7 atm) and diffusional permeability (34.7 \u00b1 6.6 \u00d7 10\u201d5 cm\/s) observed in the leptospirotic inner medullary collecting duct (IMCD) in the presence of vasopressin were unchanged, as was also the case for urea permeability (3.74 \u00b1 0.7\u00d710-5 cm\/s). These data show that acute renal failure in leptospirosis is characterized by tubular changes leading to potassium secretion probably due to a decrease in proximal sodium reabsorption. Furthermore, the inability to concentrate urine evidenced by the low P&lt;sub&gt;osm&lt;\/sub&gt; present in leptospirotic animals is due, at least in part, to IMCD resistance to vasopressin.<\/jats:p>","DOI":"10.1159\/000187069","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T10:27:44Z","timestamp":1229077664000},"page":"332-339","source":"Crossref","is-referenced-by-count":46,"title":["Renal Involvement in Leptospirosis: A Pathophysiologic Study"],"prefix":"10.1159","author":[{"given":"Antonio J.","family":"Magaldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo N.","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia H.","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio C.","family":"Seguro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino S.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,12]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/187069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000187069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:11:14Z","timestamp":1777659074000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000187069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000187069","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,12]]}}}