{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:30:02Z","timestamp":1791153002215,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T00:00:00Z","timestamp":1229040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>The expression of \u03b1&lt;sub&gt;2&lt;\/sub&gt;; \u03b1&lt;sub&gt;3&lt;\/sub&gt;; \u03b1&lt;sub&gt;5&lt;\/sub&gt;; \u03b1&lt;sub&gt;6&lt;\/sub&gt;-subunits of the \u03b2&lt;sub&gt;1&lt;\/sub&gt; [very late activation (VLA)] integrin family was studied in kidney specimens using an immunofluorescent technique. 6 specimens from normal kidney were compared with 10 specimens from patients affected by various glomerulopathies [minimal change nephropathy (MCN), membranous nephropathy (MN) and systemic lupus erythematosus nephritis (SLEN)]. On normal glomeruli, \u03b1&lt;sub&gt;3&lt;\/sub&gt; was the dominant integrin, being mainly present on podocytes and showing a linear fluorescent pattern codistributed with laminin. In MCN and SLEN, \u03b1&lt;sub&gt;3&lt;\/sub&gt; presented a normal pattern. In MN, \u03b1&lt;sub&gt;3&lt;\/sub&gt; revealed a trabecular picture on thickened glomerular basement membranes. Moreover, in stage-Ill MN, a segmental loss of \u03b1&lt;sub&gt;3&lt;\/sub&gt;-integrin was detected. In our opinion, VLA-3 may offer an interesting approach to the study of the relationships between podocytes and their substrate.<\/jats:p>","DOI":"10.1159\/000187085","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T10:27:44Z","timestamp":1229077664000},"page":"382-388","source":"Crossref","is-referenced-by-count":21,"title":["Very Late Activation-3 Integrin Is the Dominant \u03b2\n                    <sub>1<\/sub>\n                    -Integrin on the Glomerular Capillary Wall: An Immunofluorescence Study in Nephrotic Syndrome"],"prefix":"10.1159","author":[{"given":"Alberto","family":"Baraldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Furci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Zambruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Rubbiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Annessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egidio","family":"Lusvarghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2008,12,12]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/187085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000187085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:11:21Z","timestamp":1777659081000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000187085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,12]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000187085","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,12]]}}}