{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:25:04Z","timestamp":1761708304861,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T00:00:00Z","timestamp":1229385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease which is associated with pathogenic IgG autoantibodies against desmogleins (Dsg) 1 and 3. Novel therapeutic strategies such as immunoadsorption (IA) or the anti-CD20 antibody rituximab (Rtx) hold promise to be effective in severe or recalcitrant PV. &lt;i&gt;Patients and Methods:&lt;\/i&gt; In the present retrospective study, 6 patients with extensive cutaneous PV were subjected to adjuvant IA treatment while 5 patients with severe mucosal PV received adjuvant Rtx treatment. &lt;i&gt;Results:&lt;\/i&gt; Within 6 months, IA and Rtx induced excellent clinical responses which were associated with a significant reduction of prednisolone doses and a decrease in anti-Dsg-specific IgG. Over a 12-month period, 3 IA-treated patients required additional adjuvant drugs while all of the PV patients on Rtx had no or only minimal residual symptoms. &lt;i&gt;Conclusion:&lt;\/i&gt; The relative therapeutic (long-term) efficacy of IA and Rtx in cutaneous versus mucosal PV needs to be evaluated in a prospective study.<\/jats:p>","DOI":"10.1159\/000187431","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T14:43:21Z","timestamp":1229611401000},"page":"237-245","source":"Crossref","is-referenced-by-count":48,"title":["Clinical and Immunological Follow-Up of Pemphigus Patients on Adjuvant Treatment with Immunoadsorption or Rituximab"],"prefix":"10.1159","volume":"218","author":[{"given":"Martin","family":"Pf\u00fctze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Eming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Kneisel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Kuhlmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hertl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2891%2990360-B"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1568-9972%2803%2900035-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI5252"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2899%2970183-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2002.04838.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080%2F08916930600972040"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1978.tb01631.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1517%2F13543784.9.9.2017"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1196%2Fannals.1361.108"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1610-0387.2007.06342.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fnri1838"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1610-0387.2007.06602.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2008.01.012"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0625.2006.00451.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000090659"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05513.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05302.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.2006.02220.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117349"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.200535349"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa062930"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa067752"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2007.08358.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2Fjid.2008.172"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038%2F35100573"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2006.08.016"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2006.12.006"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.2.192"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/187431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/187431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:32:19Z","timestamp":1745454739000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000187431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,16]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000187431","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2008,12,16]]}}}