{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:34:19Z","timestamp":1767339259056,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Polycystic ovary syndrome (PCOS) is an insulin-resistant state with hirsutism as a common manifestation. &lt;i&gt;Objective:&lt;\/i&gt; We hypothesized that treatment with metformin would improve the cosmetic effects of intense pulsed light (IPL) therapy for hair removal in PCOS patients. &lt;i&gt;Methods:&lt;\/i&gt; In a prospective randomized controlled trial, 70 PCOS patients randomly received metformin (1,500 mg daily) + IPL therapy or IPL therapy alone for 5 IPL sessions during a 6-month period, followed by an additional 6 months of observation. Hirsutism score, homeostasis model assessment for insulin resistance (HOMA-IR), free androgen index (FAI) and patient satisfaction were evaluated at every visit. &lt;i&gt;Results:&lt;\/i&gt; Fifty-two patients finished the study. Hirsutism was significantly better controlled in the metformin group (p = 0.009). Patient satisfaction was significantly better in the metformin group at the end of the observation period (52.9 vs. 34.1%, p = 0.019). HOMA-IR and FAI scores improved after metformin + IPL treatment (p &lt; 0.05). &lt;i&gt;Conclusion:&lt;\/i&gt; Adding metformin to IPL in women with PCOS results in a significant improvement in insulin sensitivity and hirsutism.<\/jats:p>","DOI":"10.1159\/000187718","type":"journal-article","created":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T14:43:21Z","timestamp":1229611401000},"page":"231-236","source":"Crossref","is-referenced-by-count":16,"title":["Increased Insulin Sensitivity by Metformin Enhances Intense-Pulsed-Light-Assisted Hair Removal in Patients with Polycystic Ovary Syndrome"],"prefix":"10.1159","volume":"218","author":[{"given":"Hassan","family":"Rezvanian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neda","family":"Adibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Siavash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Kachuei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Shojaee-Moradie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Asilian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030424"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2803%2902106-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2003.582"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1463-1326.1999.00026.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMct0707092"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1470217"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-57-2-356"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.41.10.1257"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-007-0831-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-123-2-733"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114745"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2FS0190-9622%2803%2900777-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-72-1-83"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1080%2F09513590601005847"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.327.7421.951"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337%2Fdc06-0618"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1380269"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199608293350902"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.12.4075"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199806253382603"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0029-7844%2897%2900296-2"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2F0026-0495%2894%2990209-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeh098"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-21-11-1440"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.133.2.447"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/187718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/187718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:35:38Z","timestamp":1745454938000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000187718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,18]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000187718","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2008,12,18]]}}}