{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:55:04Z","timestamp":1761540904145,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>Background: Chronic gastritis and esophagitis are associated with changes in mucosal glycosylation patterns. Lectins represent a group of specific carbohydrate binding proteins that can be used as sensitive tools for the analysis of glycosylation patterns. Aim: To investigate the binding patterns of lectins Ulex europaeus agglutinin-I (UEA-I), Dolichos biflorus agglutinin (DBA), Helix pomatia agglutinin (HPA) and peanut agglutinin (PNA) at the gastroesophageal junction in nonerosive (NERD), erosive reflux disease (ERD) and Barrett\u2019s esophagus (BE). Methods: One hundred and twenty-two patients (female n = 53; male n = 69; controls n = 28; NERD n = 36; ERD n = 24 and BE n = 34) were included in this study. The binding patterns of lectins were examined immunohistochemically at the squamocolumnar junction, in squamous epithelium and columnar-lined epithelium. Staining patterns of lectins were semiquantitatively evaluated using an immunohistochemical score and the data were analyzed using non-parametric tests. Results: BE, as compared to the controls, was associated with specific lectin-binding patterns: lectin binding of UEA-I and DBA were significantly decreased at the superficial (p = 0.012; p = 0.00036, respectively) and at the deep glandular body (p = 0.045; p = 0.055, respectively). Comparisons of lectin-staining scores between GERD and BE revealed significant increases of UEA-I in both the stratum superficiale (p = 0.0155) and stratum spinosum (p = 0.0048) of SE in patients with BE. Notable, this change was specific for patients with BE, while no difference was observed between patients with GERD and controls. Conclusion: We found two major types of lectin-binding patterns. First, lectin-binding characteristics associated with GERD in general, and second, lectin-binding patterns which were specific for BE. Lectin UEA-I-binding proteins were specifically increased in the squamous epithelium of patients with BE. Thus, UEA-I may serve as a potential marker for BE, especially in patients with short segment BE.<\/jats:p>","DOI":"10.1159\/000187724","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T13:34:25Z","timestamp":1231508065000},"page":"201-207","source":"Crossref","is-referenced-by-count":6,"title":["Lectin UEA-I-Binding Proteins Are Specifically Increased in the Squamous Epithelium of Patients with Barrett\u2019s Esophagus"],"prefix":"10.1159","volume":"78","author":[{"given":"Helmut","family":"Neumann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Wex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"M\u00f6nkem\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda C.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Malfertheiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00953982"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3AGLYC.0000033993.98159.cc"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1711760112"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-198812000-00002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI113256"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1069076"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.femsim.2004.11.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000080310"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2970576-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2004.041533"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080%2F00365520601127158"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.45.2.172"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.05910.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00000478-199610000-00001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-3659%2801%2900338-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10735-004-3838-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004290050302"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2001.03863.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.1999.01513.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2001.03863.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.1996.v111.pm8898632"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/78\/4\/201\/4033661\/000187724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/78\/4\/201\/4033661\/000187724.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:35:40Z","timestamp":1745454940000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000187724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,2,1]]},"published-print":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000187724","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2008]]}}}