{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:06:18Z","timestamp":1777917978148,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,18]],"date-time":"2008-12-18T00:00:00Z","timestamp":1229558400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>This study is the first cytogenetic investigation of healthy relatives of patients with Balkan endemic nephropathy (BEN) who were born in nonendemic areas. Characteristics of BEN No. 3 chromosomal anomalies (extremely high frequencies of 3q25 homologue discordance \u2013 68.5 \u00b1 (SD) 5.03% vs. 6.65 \u00b1 0.95% in controls, p &lt; 0.001; chromosome breaks at 3q25 band \u2013 0.79 \u00b1 0.25% vs. 0.01% in controls, p &lt; 0.001; structural aberrations affecting 3q25 band), very high frequency of acquired chromosomal aberrations (5.74 \u00b1 0.64% vs. 1.72 \u00b1 0.3% in controls) and a family history with 1 or 2 BEN parents were identified in 5 relatives. It is proposed that they are at high risk for developing the disease and that a genetic mechanism might be involved in the etiology of BEN.<\/jats:p>","DOI":"10.1159\/000188940","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T09:00:08Z","timestamp":1230109208000},"page":"564-569","source":"Crossref","is-referenced-by-count":34,"title":["Genetic Predisposition to Balkan Endemic Nephropathy"],"prefix":"10.1159","author":[{"given":"D.","family":"Toncheva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Dimitrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,18]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/188940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000188940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:27:56Z","timestamp":1777660076000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000188940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,18]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000188940","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,18]]}}}