{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:07:03Z","timestamp":1777918023645,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:00:00Z","timestamp":1229644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:00:00Z","timestamp":1229644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>The present study was conducted to develop a special formula to predict creatinine clearance (C&lt;sub&gt;cr&lt;\/sub&gt;, ml\/min) in the elderly with chronic muscle atrophy using serum albumin (Alb, g\/dl). We obtained 90 data sets including actual body weight (BW, kg), urinary creatinine excretion (U&lt;sub&gt;cr&lt;\/sub&gt;, mg\/24 h), serum creatinine (S&lt;sub&gt;cr&lt;\/sub&gt;, mg\/dl), and Alb from 90 inpatients aged 60-92 years. Regression equations were determined between the dependent variable of Uq\/BW and the explanatory variable of Alb as follows: For males U&lt;sub&gt;Cr&lt;\/sub&gt;\/BW = 2.695Alb + 4.665 For females U&lt;sub&gt;Cr&lt;\/sub&gt;\/BW = 1.827Alb + 4.146. Then, the new predictive formula was derived from the equations: For males C&lt;sub&gt;Cr&lt;\/sub&gt; = (19Alb + 32)BW\/(100 \u00d7 S&lt;sub&gt;Cr&lt;\/sub&gt;) For females C&lt;sub&gt;Cr&lt;\/sub&gt; = (13Alb + 29)BW\/( 100 \u00d7 S&lt;sub&gt;Cr&lt;\/sub&gt;). Evaluations for the predictive error (predicted C&lt;sub&gt;cr&lt;\/sub&gt; \u2013 measured C&lt;sub&gt;cr&lt;\/sub&gt;) showed that the new formula could provide more accurate and less biased estimates of C&lt;sub&gt;cr&lt;\/sub&gt; than the Cockcroft and Gault formula could, even in patients with renal insufficiency and in those with Alb \u2264 2.8 g\/dl.<\/jats:p>","DOI":"10.1159\/000189030","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T09:00:08Z","timestamp":1230109208000},"page":"137-144","source":"Crossref","is-referenced-by-count":19,"title":["Serum Albumin for Estimating Creatinine Clearance in the Elderly with Muscle Atrophy"],"prefix":"10.1159","member":"127","published-online":{"date-parts":[[2008,12,19]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000189030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:29:07Z","timestamp":1777660147000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000189030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000189030","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,19]]}}}