{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:12:05Z","timestamp":1777918325853,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron"],"abstract":"<jats:p>From a clinical aspect, there are still a number of unsolved problems in patients with end-stage renal disease, for instance intractable malnutrition. The present study was undertaken to establish the therapeutic effect of recombinant human growth hormone (r-hGH) on the nutritional state and clarify the usefulness of the insulin-like growth factor-I (IGF-I)\/insulin-like growth factor binding protein-1 (IGFBP-1) ratio as nutritional indices for prediction of the clinical response in uremic patients on hemodialysis. Thirty hemodialysis patients (13 females and 17 males; mean age 56.7 \u00b1 15.2 years) were studied who were suffering from malnutrition and could not be treated by any of the usual nutritional therapies; they were subjected to 0.5 IU\/kg\/week of r-hGH subcutaneously after hemodialysis for 2 weeks. Blood samples were collected for measurement of the following plasma biochemical and hematological indices: serum IGF-I, IGFBP-1, growth hormone, total protein (TP), prealbumin, transferrin, albumin, serum urea nitrogen (SUN), creatinine, hematocrit, and amino acids. Immediately after r-hGH administration, SUN, essential ami-no acid and nonessential amino acid changed from 67.7 \u00b1 12.3 to 56.5 \u00b1 10.5 mg\/dl (p &lt; 0.05), from 798 \u00b1 84 to 1 115 \u00b1 208 \u03bcM\/l (p &lt; 0.05 vs. baseline), and from 2,185 \u00b1 221 to 2,814 \u00b1 621 \u03bcM\/l (p &lt; 0.05), respectively. Serum IGF-I increased markedly from 193 \u00b1 49 to 321 \u00b1 81 ng\/ml, whereas serum IGFBP-1 decreased from 139 \u00b1 13 to 81 \u00b1 19 \u03bcg\/l (p &lt; 0.05). Four weeks after r-hGH administration, serum TP and albumin increased from 5.5 \u00b1 0.2 to 6.0 \u00b1 0.3 g\/dl (p &lt; 0.05) and from 3.2 \u00b1 0.2 to 3.6 \u00b1 0.3 g\/dl (p &lt; 0.05), respectively. Serum IGF-I\/IGFBP-1 ratio was significantly higher in patients with an increase of 0.5 g\/dl or more in serum albumin than in other patients with poor response and the control group before r-hGH administration. Patients with marked improvement in serum albumin showed an IGF-I\/IGFBP-1 ratio of 2 or less. On the other hand, patients without favorable improvement in serum albumin had a higher ratio of 4 or more. We conclude that r-hGH and IGF-I improve the malnutritional state by alleviating hypoproteinemia and abnormality of serum amino acid profile in uremic patients on hemodialysis. In addition, the serum IGF-I\/IGFBP-1 ratio is useful not only as a nutritional parameter but also as a predicting index of responsiveness to r-hGH.<\/jats:p>","DOI":"10.1159\/000190243","type":"journal-article","created":{"date-parts":[[2008,12,24]],"date-time":"2008-12-24T09:02:25Z","timestamp":1230109345000},"page":"29-36","source":"Crossref","is-referenced-by-count":9,"title":["IGF-l\/IGFBP-1 as an Index for Discrimination between Responder and Nonresponderto Recombinant Human Growth Hormone in Malnourished Uremic Patients on Hemodialysis"],"prefix":"10.1159","author":[{"given":"Michitaka","family":"Shinobe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Sanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nihei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Sugino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2008,12,23]]},"container-title":["Nephron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000190243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:36:12Z","timestamp":1777660572000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000190243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,23]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000190243","archive":["Portico"],"relation":{},"ISSN":["1660-8151","2235-3186"],"issn-type":[{"value":"1660-8151","type":"print"},{"value":"2235-3186","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,23]]}}}