{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:00:15Z","timestamp":1761919215256,"version":"3.40.4"},"reference-count":45,"publisher":"S. Karger AG","issue":"Suppl. 2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2009]]},"abstract":"Sporadic multiple endocrine neoplasia type 1 (MEN1) is defined as the occurrence of tumours in two of three main endocrine tissue types: parathyroid, pituitary and pancreaticoduodenal. A prolactinoma variant or Burin variant of MEN1 was found to occur in three large kindreds, with more prolactinomas and fewer gastrinomas than typical MEN1. MEN1 tumours differ from common tumours by showing features from the <i>MEN1<\/i> gene (e.g. larger pituitary tumours). They also show various expressions of tumour multiplicity; however, pituitary tumour in MEN1 is usually solitary. Diagnosis in MEN1 carriers during childhood is not directed at cancers but at benign morbid tumours. Morbid prolactinoma occurred at the age of 5 years in one MEN1 individual; hence, this is the earliest age at which to recommend tumour surveillance in carriers. The<i> MEN1<\/i> gene shows biallelic inactivation in 30% of some types of common variety endocrine tumours (e.g. parathyroid adenoma, gastrinoma, insulinoma and bronchial carcinoid), but in only 1\u20135% of common pituitary tumours. Heterozygous knockout of <i>MEN1<\/i> in mice provides a robust model of MEN1 and has been found to support further research on anti-angiogenesis therapy for pituitary tumours. The rarity of <i>MEN1<\/i> mutations in some MEN1-like states aids the identification of other mutated genes, such as <i>AIP<\/i>, <i>HRPT2 <\/i>and <i>p27<\/i><sup>Kip1<\/sup>. We present recent clinical and basic findings about the <i>MEN1<\/i> gene, particularly concerning hereditary vs. common variety pituitary tumours.<\/jats:p>","DOI":"10.1159\/000192450","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T14:05:34Z","timestamp":1241013934000},"page":"131-138","source":"Crossref","is-referenced-by-count":18,"title":["The <i>MEN1<\/i> Gene and Pituitary Tumours"],"prefix":"10.1159","volume":"71","author":[{"given":"Sunita K.","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen M.","family":"Mateo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Marx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,4,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.12.5658"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.2.457"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2880%2980013-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-1004%281998%2911%3A4%3C264%3A%3AAID-HUMU2%3E3.0.CO%3B2-V"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-031511"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2F332085a0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1126100"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-07-0348"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000192448"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F00005792-200201000-00001"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.2003.016725"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-030675"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.2005.035766"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-1155"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819890115%2963%3A2%3C390%3A%3AAID-CNCR2820630232%3E3.0.CO%3B2-K"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2820010601%2991%3A11%3C2104%3A%3AAID-CNCR1238%3E3.0.CO%3B2-I"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.1473"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.20.16.6147-6158.2000"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0603877103"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-2843"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-2563"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1133427"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.2003-0037"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.98.3.1118"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.23.17.6075-6085.2003"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.22288"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.gastro.2005.01.058"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2000.93.5.0753"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1385%2FEP%3A16%3A3%3A187"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12022-007-0008-6"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra062285"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2879%2991062-3"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1086%2F301953"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.12.4776"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1128%2FMCB.01764-06"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1210163"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2Fbgm207"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-07-1552"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002%2Fhumu.20605"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.1834524100"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1209759"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0408836102"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0503484102"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2005.09.025"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1146812"}],"container-title":["Hormone 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