{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:08:54Z","timestamp":1777946934160,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T00:00:00Z","timestamp":1231891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T00:00:00Z","timestamp":1231891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>The comparative ventilatory responsiveness to CO&lt;sub&gt;2&lt;\/sub&gt; was studied in 13 chronic bronchitics and 14 emphysematous patients, all exhibiting respiratory insufficiency and with FEV&lt;sub&gt;1&lt;\/sub&gt; less than 1,500 ml. The gas inhaled was enriched with oxygen (F&lt;sub&gt;1&lt;\/sub&gt;O&lt;sub&gt;2&lt;\/sub&gt; = 0.6) and contained 6% CO&lt;sub&gt;2&lt;\/sub&gt;, and measurements were taken when the patients had reached a stable state. The ratio \u0394VE\/\u0394Paco&lt;sub&gt;2&lt;\/sub&gt;, which represents the ventilatory responsiveness to CO&lt;sub&gt;2&lt;\/sub&gt;, was higher in the emphysematous patients (1.18 \u00b1 0.51 liters\u00b7min-1- Torr-1) than in the bronchitics (0.76 \u00b1 0.34, \u03c1 &lt; 0.025), but the deviation on either side of the mean was large in each group. The ventilatory responsiveness to CO&lt;sub&gt;2&lt;\/sub&gt; was proportional to the initial Paco&lt;sub&gt;2&lt;\/sub&gt;, FEV&lt;sub&gt;1&lt;\/sub&gt;, total airways resistance, total pulmonary work and especially to inspiratory mechanical work done on the lung (r=-0.72, p &lt; 0.001). The difference in ventilatory responsiveness to CO&lt;sub&gt;2&lt;\/sub&gt; between the bronchitic and emphysematous patients may be explained by the difference in energy expended in breathing. It was not possible to exclude an effect due to a difference in sensitivity within the respiratory centers, since inspiratory mechanical work was not measured during CO&lt;sub&gt;2&lt;\/sub&gt; inhalation. It was thought likely that mechanical factors play a triggering role, in that they cause a fall in ventilatory responsiveness to CO&lt;sub&gt;2&lt;\/sub&gt; and hypercapnia, the latter causing the central hyposensitivity which maintains the retention of CO&lt;sub&gt;2&lt;\/sub&gt;.<\/jats:p>","DOI":"10.1159\/000193733","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T03:53:22Z","timestamp":1232423602000},"page":"188-198","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Study of the Ventilatory Responsiveness to CO\n                    <sub>2<\/sub>\n                    in Bronchitic and Emphysematous Patients with Chronic Respiratory Failure"],"prefix":"10.1159","author":[{"given":"E.","family":"Weitzenblum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-P.","family":"Parini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Roeslin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.-C.","family":"Ravault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Oudet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,14]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/193733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000193733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:01:42Z","timestamp":1777755702000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000193733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000193733","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,14]]}}}