{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:09:12Z","timestamp":1777946952344,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T00:00:00Z","timestamp":1231891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,14]],"date-time":"2009-01-14T00:00:00Z","timestamp":1231891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>In 17 patients, breathing room air and pure oxygen, with histologically proven cirrhosis of the liver and portocaval encephalopathy grade I, static and dynamic lung volumes, closing capacity and arterial blood gases were determined. Furthermore, CO&lt;sub&gt;2 &lt;\/sub&gt;response curves were provided and mouth occlusion pressure measurements were carried out. The residual volume was found to be increased (130 \u00b1 8% of predicted) which resulted in decreased vital capacity (79 \u00b1 2% of predicted) with total lung capacity being normal (94 \u00b1 2% of predicted). Closing capacity was increased to 134 \u00b1 5% of the predicted value. Gas exchange for oxygen was impaired (AaDO&lt;sub&gt;2&lt;\/sub&gt;= 262 \u00b1 30% of predicted). Arterial Po&lt;sub&gt;2&lt;\/sub&gt;, however, was within normal range Pao&lt;sub&gt;2&lt;\/sub&gt; = 84 \u00b1 3.6 mm Hg) due to hyperventilation (Paco&lt;sub&gt;2 &lt;\/sub&gt;= 28.1 \u00b1 0.8 mmHg). Hypoxic ventilatory stimulation could be excluded because inspiration of pure oxygen caused no change of Paco&lt;sub&gt;2&lt;\/sub&gt; (Paco&lt;sub&gt;2&lt;\/sub&gt; = 27.3 -f 0.7 mm Hg and Pao&lt;sub&gt;2&lt;\/sub&gt; = 465 + 16.9 mm Hg with F\u03b9o&lt;sub&gt;2&lt;\/sub&gt; = 1.0). The slope of the CO&lt;sub&gt;2&lt;\/sub&gt; response curves was normal, the mouth occlusion pressures, however, were higher than the predicted value: up to Paco&lt;sub&gt;2&lt;\/sub&gt; of 55 mm Hg. The slope of these curves being smaller than predicted. The results show that in patients with portocaval encephalopathy the lung function is disturbed due to premature airway closure with consequently decreased regional ventilation: perfusion ratios and that regulation of ventilation is impaired by a loss of sensitivity for CO, with high basal output of the respiratory centers not related to CO&lt;sub&gt;2&lt;\/sub&gt;<\/jats:p>","DOI":"10.1159\/000194236","type":"journal-article","created":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T10:51:04Z","timestamp":1232967064000},"page":"307-317","source":"Crossref","is-referenced-by-count":0,"title":["Lungenfunktion, Gasaustausch und Atemregulation bei Patienten mit portokavaler Enzephalopathie"],"prefix":"10.1159","author":[{"given":"G.W.","family":"Sybrecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Fabel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,14]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/194236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000194236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:07:32Z","timestamp":1777756052000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000194236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000194236","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,14]]}}}