{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:09:19Z","timestamp":1777946959353,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T00:00:00Z","timestamp":1289433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>32 subjects affected with mitral stenosis were investigated. All the subjects were nonsmokers, and none had any histories of lung disease. Mean pulmonary artery pressure (P&lt;sub&gt;Ap&lt;\/sub&gt;) and mean wedge pressure (P&lt;sub&gt;c&lt;\/sub&gt;) were obtained by right catherization and compared with a number of sensitive tests for the detection of incipient bronchial obstruction: dynamic and static lung compliance (C&lt;sub&gt;L&lt;\/sub&gt;dyn, C&lt;sub&gt;L&lt;\/sub&gt;Stat); maximal expiratory flows at 50% and 25% (MEF&lt;sub&gt;50%&lt;\/sub&gt;, MEF&lt;sub&gt;25%&lt;\/sub&gt;) of the forced vital capacity (FVC); closing volume (CV); airway resistance (Raw), and residual volume (RV). It was established that the most sensitive tests for the detection of bronchial obstruction, i.e. the difference between C&lt;sub&gt;L&lt;\/sub&gt;dyn and C&lt;sub&gt;L&lt;\/sub&gt;Stat due to the reduction of C&lt;sub&gt;L&lt;\/sub&gt;dyn and the decrease of the instantaneous flows at 50% and 25% FVC, are in very good correlation with the changes in lung hemodynamics. The most significant correlations exist between Pc and C&lt;sub&gt;L&lt;\/sub&gt;dyn (r = 0.527), between P&lt;sub&gt;Ap&lt;\/sub&gt; and R&lt;sub&gt;AW&lt;\/sub&gt; (r = 0.554) and between P&lt;sub&gt;Ap&lt;\/sub&gt; and MEF&lt;sub&gt;50%,&lt;\/sub&gt; (r = 0.320). CV and RV were not significantly correlated with P&lt;sub&gt;Ap&lt;\/sub&gt; and P&lt;sub&gt;c&lt;\/sub&gt;. Les alterations pulmonaires initiales des voies a\u00e9riennes p\u00e9riph\u00e9riques int\u00e9ressent non seulement le pneumologue, mais aussi le cardiologue. Leur d\u00e9couverte pr\u00e9coce et la d\u00e9termination de leur origine ont une signification pratique tr\u00e8s importante. Le pr\u00e9sent travail a pour but d\u2019\u00e9valuer les relations entre les alt\u00e9rations pr\u00e9coces de la function respiratoire et les modifications h\u00e9modynamiques inh\u00e9rentes \u00e0 l\u2019affection pri-maire, c\u2019est-\u00e0-dire la st\u00e9nose mitrale.<\/jats:p>","DOI":"10.1159\/000194400","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T03:01:09Z","timestamp":1289444469000},"page":"25-29","source":"Crossref","is-referenced-by-count":0,"title":["Influence d\u2019une h\u00e9modynamique pulmonaire perturb\u00e9e sur l\u2019obstruction bronchique pr\u00e9coce chez les patients souffrant de troubles mitraux"],"prefix":"10.1159","author":[{"given":"L.","family":"Matanov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bachtchevandjieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kirkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,11,11]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/194400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000194400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:09:26Z","timestamp":1777756166000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000194400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000194400","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,11]]}}}