{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:09:23Z","timestamp":1777946963549,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T00:00:00Z","timestamp":1231977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T00:00:00Z","timestamp":1231977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"abstract":"<jats:p>Oxitropium bromide (Ba 253) is a new inhaled bronchodilating agent with anticholinergic properties. The effect of this compound (100 \u03bcg) was compared to that of ipratropium bromide (40 \u03bcg), the \u03b2&lt;sub&gt;2&lt;\/sub&gt;-receptor stimulant fenoterol (400 \u03bcg) and placebo in 8 patients with exercise-induced asthma. The drugs were administered by metered dose inhalers, after which exercise tests were performed on ergometer cycles at the times of the drugs\u2019 maximal effects. Forced expiratory volume during 1 s and vital capacity were recorded basally, repeatedly during 20 min after exercise and following the inhalation of isoprenaline (160 \u03bcg) which was given 20 min after exercise. Fenoterol possessed a very good protective effect against exercise-induced bronchoconstriction in all patients, whereas the other drugs differed very little from placebo. Thus, only 4 patients did benefit from ipratropium bromide, 1 patient from oxitropium bromide and 2 patients from placebo. No side effect occurred. In the doses used the two anticholinergic agents ipratropium bromide and oxitropium bromide were less effective than a \u03b2&lt;sub&gt;2&lt;\/sub&gt;-adrenoreceptor stimulant like fenoterol in protecting against exercise-induced asthma.<\/jats:p>","DOI":"10.1159\/000194464","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:10:33Z","timestamp":1777756233000},"page":"57-63","source":"Crossref","is-referenced-by-count":0,"title":["Oxitropium Bromide, Ipratropium Bromide and Fenoterol in Exercise-Induced Asthma"],"prefix":"10.1159","author":[{"given":"Kjell","family":"Larsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2009,1,15]]},"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000194464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:10:33Z","timestamp":1777756233000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000194464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000194464","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,15]]}}}