{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:36:40Z","timestamp":1782473800405,"version":"3.54.5"},"reference-count":19,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2009]]},"abstract":"<i>Background:<\/i> Skin lesion is the most frequent manifestation of adverse drug reactions. Drug-induced cutaneous hypersensitivity and drug-induced acute interstitial nephritis might share a similar mechanism involving drug-specific T cells. We thus investigated the renal outcome of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), the most severe drug-induced cutaneous hypersensitivity, and hypothesize that skin detachment in SJS\/TEN might be associated with acute renal failure (ARF). <i>Methods:<\/i> 234 hospitalized patients were retrospectively classified into an SJS\/TEN group (skin detachment) or an erythematous multiforme majus group (target-like exanthema alone). <i>Results:<\/i> Both drugs and chronic kidney disease (CKD) are associated with SJS\/TEN. The SJS\/TEN group was more likely to develop ARF than the erythematous multiforme majus group (18.8 vs. 4.3%, p < 0.05) despite similar initial creatinine clearance. In the ARF patients, RIFLE-F class, dialysis and long-term dialysis were 25, 15 and 5%, respectively. The offending drugs in ARF were also associated with CKD. Hyponatremia and late hypokalemia were more frequently in the SJS\/TEN group (15.6 vs. 2.9%, 7.3 vs. 0.7%, respectively, p < 0.05). Sepsis, allopurinol, antibiotics, NSAIDs, CKD and hypoalbuminemia (OR: 18.8, 9.8, 10.1, 9.0, 5.3 and 3.3, respectively, p < 0.05) were the risk factors of developing ARF. <i>Conclusion:<\/i> ARF, the need for dialysis, and late hypokalemia could be the consequences of SJS\/TEN. Skin detachment after certain medication might implicate the associated ARF, especially in CKD patients.<\/jats:p>","DOI":"10.1159\/000195632","type":"journal-article","created":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T15:51:04Z","timestamp":1232985064000},"page":"633-638","source":"Crossref","is-referenced-by-count":52,"title":["Acute Renal Failure and Its Risk Factors in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis"],"prefix":"10.1159","volume":"29","author":[{"given":"Chi-Chih","family":"Hung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Chuan","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Jyh","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tox.2004.12.022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh485"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0409500102"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006050418"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.138.8.1019"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2005.07023.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1592%2Fphco.21.15.1233.33901"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2000.00061.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2165%2F00002018-199513010-00007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.129.1.92"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc2872"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1445-5994.2005.00790.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-139X.2003.03011.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2003.12.045"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080%2F00015550310007166"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.131.10.1212"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2F428486a"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1535-7511.2006.00089.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200005253422107"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/195632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/195632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:20:02Z","timestamp":1745450402000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000195632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2009,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000195632","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}