{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:39Z","timestamp":1790232579984,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Products of cyclin-dependent kinase inhibitor <i>p<\/i>16<sup>INK4A<\/sup>and mitotic arrest defective protein 2 (<i>MAD<\/i>2) genesare key regulator proteins at the G1 restriction point and mitotic checkpoint of the cell cycle. The objective of this study was to investigate the role of promoter methylation of <i>p<\/i>16<sup>INK4A<\/sup> and <i>MAD<\/i>2 genes in gastric marginal-zone B-cell lymphoma (MZBCL). <i>Materials and Methods:<\/i> Gastric biopsies from 40 patients were analyzed by methylation-specific polymerase chain reaction, and the methylation status was compared with the results of BCL10 expression and t(11;18)(q21;q21) translocation. <i>Results and Conclusion:<\/i><i>p<\/i>16<sup>INK4A<\/sup> was methylated in 30 of 40 MZBCLs (75%). The lymphomas with <i>p<\/i>16<sup>INK4A<\/sup> methylation tended to be negative for t(11;18)(q21;q21) (p = 0.011). <i>MAD<\/i>2 gene was methylated in 23 of 38 MZBCLs (61%). Lymphomas with <i>MAD<\/i>2 gene methylation more frequently expressed BCL10 (p = 0.037). These methylation profiles suggest that <i>p<\/i>16<sup>INK4A<\/sup> and <i>MAD<\/i>2 gene may play a role in the pathogenesis of MZBCL via different pathways; <i>MAD<\/i>2 gene is <i>Helicobacter pylori <\/i>independent with a close association with BCL10 while <i>p<\/i>16<sup>INK4A<\/sup> is <i>H. pylori<\/i> dependent with an inverse correlation with the t(11;18)(q21;q21) translocation.<\/jats:p>","DOI":"10.1159\/000195698","type":"journal-article","created":{"date-parts":[[2009,1,31]],"date-time":"2009-01-31T15:30:40Z","timestamp":1233415840000},"page":"217-224","source":"Crossref","is-referenced-by-count":11,"title":["Methylation of <i>p<\/i>16<sup>INK4A<\/sup> and Mitotic Arrest Defective Protein 2 (<i>MAD<\/i>2) Genes in Gastric Marginal-Zone B-Cell Lymphomas"],"prefix":"10.1159","volume":"120","author":[{"given":"Sanghui","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Mee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Haeng","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Chul","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hyeh","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2009,1,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(98)00112-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.3.261"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.52.1.51"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2006.00955.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.11.003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000402"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0169-5002%2800%2900223-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0215%2820010720%2995%3A4%3C223%3A%3AAID-IJC1038%3E3.0.CO%3B2-L"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F21.12.2293"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.05.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V99.1.3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1203018"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.10.087"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1715"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2002.33047"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2991409-F"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS1383-5742%2896%2900050-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093%2Fcarcin%2F21.11.2091"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-05-2096"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1010632309113"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2800%2903571-6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007%2Fs535-002-8127-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-05-3602"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbamcr.2007.03.014"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-03-3455"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038%2F35053094"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2006.04.172"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/195698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/195698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:20:29Z","timestamp":1745450429000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000195698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000195698","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008]]}}}